Numerical Simulation of Second-Order Microfluidic Filter
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RESEARCH ARTICLE
Numerical Simulation of Second-Order Microfluidic Filter Wenting Wu1
•
Zhongcheng Liang1,2 • Le Zhang1 • Rui Zhao1,2 • Meimei Kong1,2
Received: 22 February 2016 / Revised: 1 June 2017 / Accepted: 14 December 2018 Ó The National Academy of Sciences, India 2019
Abstract In this paper, we present a microfluidic filter to improve mixing index and eliminate the pulsatile component within microfluidic devices, which is similar to a second-order RC low-pass filter in electronics. COMSOL Multiphysics, a kind of simulation software, is used to evaluate the analytical method and the efficiency of the device. Compared with the results obtained from the equivalent circuit theory, the simulation method has been verified. In addition, the equivalent circuit theory, in other words the fluid dynamical equivalent of Ohm’s law, is adopted to make the theoretical analysis. This microfluidic filter is equipped with multiple simple channels and microcavities having elastic membrane at the top layer, just like the series–parallel connection of resistors and capacitors. Based on the results, one microcavity is equivalent to first-order filter and two microcavities in series equal second-order filter which shows the better filtering effect. Actually, when the driving frequency exceeds 60 Hz, this device can export almost steady fluid. The mixing effect is & Zhongcheng Liang [email protected] Wenting Wu [email protected]; [email protected] Le Zhang [email protected] Rui Zhao [email protected] Meimei Kong [email protected] 1
School of Photoelectric Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
2
Center of Optofluidic Technology, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
improved compared with the simple microfluidic junctions. The combined application of microfluidics and equivalent circuit theory will gain insightful ideas and practical design methods for developing unique microfluidic devices to address a broad range of biological and chemical challenges. Keywords Microfluidic filter Second-order RC low-pass filter The equivalent circuit theory Microchannel Microcavity
1 Introduction With the development of theoretical study of microfluidics and microprocessing technology [1, 2], microfluidic labon-a-chip dealing with precise manipulation of small volumes of fluid has widely applied in biological and chemical processes [3–5], such as preparation, reaction, separation, detection of samples and cell culture. Because of the characteristics of miniaturization, it is safer for toxic and hazardous tests than conventional methods. For scarce or expensive reagents, it not only reduces waste and saves the money, but also ensures the smooth progress of the experiment. Because of the advantages of miniaturization and portability, it can provide point-of-care services in medical treatment. In addition to the above advantages, there are still several limitations to be overcome. One possible limitation is inadequate mixing if mi
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