Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study
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Oleic Acid (OA), A Potential Dual Contrast Agent for Postmortem MR Angiography (PMMRA): A Pilot Study* Zhi-yuan XIA1#, Christine BRUGUIER2, Fabrice DEDOUIT3, Silke GRABHERR2, Marc AUGSBURGER2, Bei-bei LIU4 1 Institute of Evidence Law and Forensic Science, China University of Political Science and Law (CUPL), Key Laboratory of Evidence Law and Forensic Science, Ministry of Education, Beijing 100088, China 2 University Center of Legal Medicine, Lausanne-Geneva (CURML), Lausanne CH1000, Switzerland 3 Service de Médecine Légale, Hôpital de Rangueil, Toulouse 50032, France 4 Dian Research Center for Postmortem Imaging & Angiography, Beijing 100192, China Huazhong University of Science and Technology 2020
Summary: Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography (PMMRA). However, in this emerging field, the number of suitable kinds of liquid is still very limited. The objective of this research is to compare MR images of oleic acid (OA) with paraffin oil (PO) in vitro and in ex situ animal hearts, in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA. In vitro, OA, PO and water (control) were introduced into three tubes separately and T1weighted-spin echo (T1w-SE) and T2w-SE images were acquired on a 1.5T MR scanner. In the second experiment, OA and PO were injected into left coronary artery (LCA) and left ventricle (LV) of ex situ bovine hearts and their T1w-SE, T2wSE, T1w-multipoint Dixon (T1w-mDixon) and 3DT2w-mDixon images were acquired. The overall results indicate that OA may have a potential to be used as a dual (T1 and T2 based) contrast agent for PMMRA when proper sequence parameters are utilized. However, as the pilot study was based on limited number of animal hearts, more researches using OA in cadavers are needed to validate our findings. Key words: postmortem magnetic resonance angiography; perfusate; contrast agent; oleic acid; paraffin oil; heart
In forensic medicine, the minimally or non invasive autopsy approach using postmortem cross-sectional imaging such as postmortem computed tomography (PMCT) and postmortem magnetic resonance imaging (PMMR) have been implemented as a useful adjunct or an alternative to conventional invasive autopsy in some countries of the world[1–4]. PMCT, because of its easier availability and affordability, has already been routinely used in postmortem investigations in some forensic institutes across Europe, Japan, Australia and so on[5–8]. A general agreement is that PMCT can well detect bone fracture, gas collection, calcification, foreign bodies and massive hemorrhages[9–13]. However, the major weakness associated with it is the failure to provide good visualization of the cardiovascular system, an important aspect to accurately diagnose coronary artery disease[2, 14, 15]. Corresponding author, Zhi-yuan XIA, E-mail: [email protected] * This project was supported by a grant from China Scholarship Council (No. CSC 201707070113). #
In the past decade, addition of angiogra
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