Omega-3 Fatty Acids in Cancer: Insight into the Mechanism of Actions in Preclinical Cancer Models
Worldwide, the incidences of cancer are rising. Various environmental and genetic factors are predisposing individuals to cancer. Majority of these factors result in upregulation of pro-survival pathways, downregulation of tumor suppressors, and chronic i
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Asavari A. Joshi, Mahabaleshwar V. Hegde, and Sharad P. Adekar Abbreviations
ALX/FPR2 AP1 Bak BAX bcl-2 BCRP bFGF BLT1 Bv8 CCL2 CCR5 ChemR23 COX cPLA2 CXCL12 CYP450 DCA DHA DRM EDPs EETs EEQs eFoX EGF EGFR EGFR EPA EMT ER ETC
Lipoxin A4 receptor/formyl peptide receptor 2 (ALX/FPR2) Activator protein 1 Bcl-2 homologous antagonist killer Bcl-2-associated X protein B-cell lymphoma 2 Breast cancer resistance protein Basic fibroblast growth factor Leukotriene B4 receptor 1 Prokineticin-2 Chemokine (C–C motif) ligand 2 C–C chemokine receptor type 5 Chemerin Receptor 23 Cyclooxygenase Cytosolic phospholipases A2 C–X–C motif chemokine 12 Cytochrome P450 Dichloroacetate Docosahexaenoic acid Detergent-resistant membranes Epoxydocosapentaenoic acids Epoxyeicosatrienoic acids Epoxyeicosatetraenoic acids Electrophile oxo-derivative Epidermal growth factor Epidermal growth factor receptor Epithelial growth factor receptor Eicosapentaenoic acid Epithelial–mesenchymal transition Estrogen receptor Electron transport chain
A.A. Joshi M.V. Hegde Center for Nutrition Health and Disease, IRSHA, Bharati Vidyapeeth Deemed University, Dhankawadi, Pune Satara Road, Pune, 411 043, India e-mail: [email protected] M.V. Hegde e-mail: [email protected] S.P. Adekar (&) Western IRB, Puyallup, WA 98374-2115, USA e-mail: [email protected] © Springer International Publishing Switzerland 2016 M.V. Hegde et al. (eds.), Omega-3 Fatty Acids, DOI 10.1007/978-3-319-40458-5_12
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FA FASN GPR120 GPR32 HEPEs HER-2 HETEs HGF HIF HMGB1 HMGCoAR HUVECs HEPE ICAM-1 IGF-1R IL-1 IL-10 IL-6 iNOS JNK LA LC-PUFA LOX LTB4 MAPKs MCP-1 M-CSF MMPs MRPs MTP w-3 w-6 NF-kB NO nrf2 OSM PCNA PDGF PDH PDK Pgp/ABCB1 PI3K/mTOR PKC PMN PPARγ PPREs PUFA ROS RXR SOCI
Fatty acids Fatty acid synthase G protein-coupled receptor 120 G protein-coupled receptor 32 Hydroxyeicosapentaenoic acids Human epidermal growth factor receptor 2 Hydroxyeicosatetraenoic acids Hepatocyte growth factor Hypoxia-inducible factor High-mobility group box-1 3-hydroxy-3methylglutaryl-coenzyme A reductase Human umbilical vein endothelial cells Hydroxyeicosapentaenoic acid Intercellular adhesion molecule 1 Insulin-like growth factor 1 receptor Interleukin 1 Interleukin 10 Interleukin 6 Inducible nitric oxide synthase c-Jun N-terminal kinas Linoleic acid Long-chain polyunsaturated fatty acid Lipoxygenase Leukotriene B4 Mitogen-activated protein kinases Monocyte chemotactic protein 1 Macrophage colony-stimulating factor Matrix metalloproteases Multidrug resistance-related proteins Mitochondrial permeability transition Omega-3 Omega-6 Nuclear factor-kappaB Nitric oxide Nuclear factor (erythroid-derived 2)-like 2 Oncostatin M Proliferating cell nuclear antigen Platelet-derived growth factor Pyruvate dehydrogenase Pyruvate dehydrogenase kinase P-glycoprotein/ATP-binding cassette subfamily B member Phosphoinositide 3-kinase/mammalian target for rapamycin Protein kinase C Polymorphonuclear Peroxisome proliferator-activated receptors PPAR response elements Polyunsatur
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