Opinion: Imagine 5P3A Global Health
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COMMENTARY
Opinion: Imagine 5P3A Global Health Igor Gonda1 Received: 28 June 2019 / Accepted: 14 October 2019 © The Drug Information Association, Inc 2020
Imagine the day when you will be making decisions about your health and therapeutic interventions based on both the detailed information about yourself and the history of your closest relatives as well as on health information from a cohort of people who are the most similar to you—the “twins” precisely selected from a database of billions of people. It will be a group matched for their genetics, disease and therapeutic history, lifestyle, “biomarkers,” and other factors deemed important for your health. And, for sure, you and they will throw into the mix the personal microbiomes as these may turn out to be one of the key factors for the happy homeostasis for you and people like you.
5P3A—What is it and What Could Be in it for You? If you Participate in this global information sharing system, you will get advice which will be as Precise for you as possible because it will be based on detailed data from you and a matched group Personalized for you. Every day, the inputs from you and your cohort will be used to improve the precision of your healthcare aiming at achieving your personal health goals. And this feedback will be based also on information from people “like you” who are already ahead of you in their health history—it should be therefore strongly Predictive and could be used for Preventive action against diseases and their progression—whether “natural” or iatrogenic. Effectively, as a member of this health alliance, you will sign up for a life-time n = 1 “adaptive clinical trial” in which your key health management decisions will be made on the best information available in real time from the analyses of a large number of n = 1 “trials” of participants similar to you
* Igor Gonda [email protected] 1
Respidex LLC, San Francisco, CA, USA
and, naturally, including yourself with your longitudinal history (from “pre-womb to tomb” [1]. And you will be doing something good for many others: your daily data contributions will become a valuable addition to the continuous improvement of the global health management. Sounds familiar to some of you? Yes, there is a prototype version of this on www.patientslikeme.com [2]. Naturally, I expect that you would not want to participate with much enthusiasm unless this “system” is Attractive for you. And this grand dynamic Wikipedia of health must be Accessible to you and all to derive the full benefit of the experience of as much of the humankind as possible—breaking through political, legal, and other “protectionist” barriers. Last, but not least, all of this must be Affordable to you and all the millions, and perhaps, billions of participants. These 3 As form the foundation of the 5P3A global healthcare (Fig. 1).
What else is Coming in 5P3A? If you are not into your personal data collecting wearables yet, think about it: your life is unlikely to be a straight line or a smooth curve in time without kinks in you
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