Opioids prescribing trend between 2013 and 2017 in the Lisbon and Tagus Valley region, Portugal
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SHORT RESEARCH REPORT
Opioids prescribing trend between 2013 and 2017 in the Lisbon and Tagus Valley region, Portugal Daniel Caldeira1,2,3 · Paula Broeiro1,4 · Fátima Cimadeira1 · João Costa1,3 · António Lourenço1,5 · Cristina Meireles1 · Mara Pereira Guerreiro1,6,7 · Nadine Ribeiro1,7 on behalf of the Pharmacy and Therapeutics Committee of ARSLVT Received: 9 February 2020 / Accepted: 11 November 2020 © Springer Nature Switzerland AG 2020
Abstract Background In the United States of America, the increased use of opioids is associated with serious risks, such as overdose, opioid use disorder and death. In Portugal, data about the use of these drugs are scarce. Objective Characterize the prescribing patterns of opioids in the Health Administrative Region of Lisbon and Tagus Valley. Methods Observational, retrospective descriptive analysis of the prescription of opioid drugs through the Health Administrative Region database from 2013 to 2017. The outcomes analysed were the defined daily dose (DDD) per year and the defined daily dose per 1000 inhabitants per year (DID). Results The prescription of opioid drugs in this region has increased approximately 1.5-fold over a 4 year period (totals of 4.32 million DDD and 3.25 DID in 2013 to totals of 7.21 million DDD and 5.42 DID in 2017). The opioids with the greatest absolute increase in this period were tramadol, tapentadol and codeine. Conclusion The prescription of opioid drugs has increased approximately 1.5-fold over a 4 year period in the ambulatory care of one of the main health administrative regions in Portugal. This trend warrants monitoring and suggests the need for highlighting good practices for opioids prescribing. Keywords Opioid · Pharmacoepidemiology · Prescription pattern
Impacts on practice * Mara Pereira Guerreiro [email protected] 1
Pharmacy and Therapeutics Committee of ARSLVT – Comissão de Farmácia e Terapêutica da Administração Regional de Saúde de Lisboa e Vale do Tejo, Lisboa, Portugal
Serviço de Cardiologia, Centro Cardiovascular da Universidade de Lisboa ‑ CCUL, Faculdade de Medicina, Hospital Universitário de Santa Maria (CHULN), CAML, Universidade de Lisboa, Lisbon, Portugal
2
3
Laboratório de Farmacologia Clínica e Terapêutica, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
4
Instituto de Medicina Preventiva, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
5
NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal
6
Escola Superior de Enfermagem de Lisboa, Lisbon, Portugal
7
CiiEM, Instituto Universitário Egas Moniz, Monte de Caparica, Portugal
• The prescription of opioids merits longitudinal monitor-
ing, to characterize trends and patterns that may signal quality and safety issues. • Pharmacy and Therapeutics Committees may contribute to the judicious use of opioid analgesics by performing a monitoring and educational role.
Introduction In the United States of America (USA), the use of opioid drugs increased in the last two decades [1], without being accompanied
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