Optical Biosensor Using Near Infrared Laser for Enhancement of Detection Accuracy
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https://doi.org/10.1007/s11664-020-08384-4 Ó 2020 The Minerals, Metals & Materials Society
Optical Biosensor Using Near Infrared Laser for Enhancement of Detection Accuracy NGUYEN VAN SAU,1 QUANG MINH NGO,2,3,4 THANG BACH PHAN,5,6 NGOC QUYEN TRAN,7,8 and TAN TAI NGUYEN9,10 1.—School of Basic Science, Tra Vinh University, Tra Vinh City 87000, Vietnam. 2.—University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 3.—Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 4.—Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 5.—Vietnam National University, Ho Chi Minh City, Vietnam. 6.—Center for Innovative Materials and Architectures, Ho Chi Minh City, Vietnam. 7.—Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 700000, Vietnam. 8.—Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City 700000, Vietnam. 9.—Department of Materials Science, School of Applied Chemistry, Tra Vinh University, Tra Vinh City 87000, Vietnam. 10.—e-mail: [email protected]
This work presents the figures of merit of an optical sensor using a prism based on surface plasmon resonance (SPR). A combination of a prism coated with a thin Ag layer and a wavelength of 1064 nm was used for SPR excitation. The simulated results showed that the sensor coated with a Ag layer of 60 nm yielded good response with a detection accuracy of 14 times that obtained using a wavelength of 633 nm. The sensor using a wavelength of 1064 nm showed a quality factor of around 1027.4/° and a penetration depth of 384.4 nm, which were 9.3 times and 3.5 times better, respectively, than those obtained when using a wavelength of 633 nm. The enhancement of the detection accuracy and the penetration depth of the sensor using a wavelength of 1064 nm offer advantages for the detection of bio-targets in biomedical and food applications. Key words: Detection accuracy, optical sensor, penetration depth, sensitivity, surface plasmon resonance
INTRODUCTION Optical sensors utilizing surface plasmon resonance (SPR) have been widely studied and used for different applications in chemistry, biology, environment and biomedicine.1–5 The SPR effect occurrs at the boundary between two surfaces that have opposite dielectric constants, e.g., metal and glass. Use of the SPR effect for sensing applications allows label-free sensing and real-time monitoring.6–18 Andreas Otto and Kretschmann-Rather pioneered a study of the SPR effect based on prisms with thin
(Received February 20, 2020; accepted July 31, 2020)
film deposition.19,20 The sensitivity and the detection accuracy of the optical sensor can be optimized by controlling the metal layer thickness and the operating wavelength. Most optical sensors based on this structure utilize a wavelength of 633 nm for SPR excitat
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