Oral Mucosal Drug Delivery and Therapy
This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route
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The CRS flagship book series, Advances in Delivery Science and Technology, published in partnership with Springer, will serve as a wider forum for the dissemination of knowledge relating to delivery, science, technology, and innovation to the benefit of CRS members and to the general scientific community. Our aim is to deliver high-quality volumes edited by authoritarians and written by opinion leaders from around the globe. More information about this series at http://www.springer.com/series/8875
Michael J. Rathbone • Sevda Şenel • Indiran Pather Editors
Oral Mucosal Drug Delivery and Therapy
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Editors Michael J. Rathbone ULTI Pharmaceuticals Ltd. Hamilton New Zealand Sevda Şenel Hacettepe University Faculty of Pharmacy Ankara Turkey
Indiran Pather California Northstate University College of Pharmacy Elk Grove California USA
ISSN 2192-6204 ISSN 2192-6212 (electronic) Advances in Delivery Science and Technology ISBN 978-1-4899-7557-7 ISBN 978-1-4899-7558-4 (eBook) DOI 10.1007/978-1-4899-7558-4 Library of Congress Control Number: 2015932505 Springer New York Heidelberg Dordrecht London © Controlled Release Society 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer is part of Springer Science + Business Media (www.springer.com).
To my mother… I am unable to express my love and gratitude in words, so let me just say thank you for sacrificing so many precious moments of your own life to assure my happiness and success. MJR Canım anneme … Bugüne kadar bana verdiğin karşılıksız sevgi, özveri ve güvenle yaşamımı anlamlı kıldın, sonsuz sevgi ve teşekkürlerimle… SŞ To my mother… you always gave me unconditional love, devotion and trust, which made my life momentous. Thank you with my love forever… SŞ To my mother … you are the most loving and caring person I have known, and you always had complete trust and faith in your children – thank you. IP
Preface
Academia and industry have expressed a high interest throughou
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