Osteosarcoma
This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressiv
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Osteosarcoma A Multidisciplinary Approach to Treatment
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Osteosarcoma
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Takafumi Ueda • Akira Kawai Editors
Osteosarcoma A Multidisciplinary Approach to Treatment
Editors Takafumi Ueda Osaka University Osaka, Japan
Akira Kawai National Cancer Center Hospital Tokyo, Japan
Osaka National Hospital Osaka, Japan
ISBN 978-4-431-55695-4 ISBN 978-4-431-55696-1 DOI 10.1007/978-4-431-55696-1
(eBook)
Library of Congress Control Number: 2016930103 Springer Tokyo Heidelberg New York Dordrecht London # Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Japan KK is part of Springer Science+Business Media (www.springer.com)
Preface
Among a variety of bone and soft-tissue sarcomas, osteosarcoma is one of the most difficult to treat, affecting adolescent and young adult patients with a survival rate of less than 10–15 %, even after amputation, because of the development of pulmonary metastasis. However, following the introduction of effective chemotherapy, including doxorubicin, high-dose methotrexate, cisplatin, and ifosfamide, in the late 1970s and 1980s, the prognosis of osteosarcoma improved dramatically, and it has now become a treatable disease after a long history of inevitable fatality. The “giants” of osteosarcoma treatment, including Dr. N Jaffe, Dr. G Rosen, and Dr. R Marcove, played a major role in this revolution in the United States, and thereafter the treatment was introduced in Japan and quickly adopted, pioneered by a number of notable Japanese specialists including Dr. S Yamawaki, Dr. H Fukuma, and Dr. N Kawaguchi. Now, 40 years later, over 60 % of patients with osteosarcoma can survive the disease with multidisciplinary treatment including neoadjuvant chemotherapy for about 1 year and wide local excision of the primary tumor. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis has contributed to this improvement in survival. Limb-salvage surgery is
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