Primary meningeal osteoblastic osteosarcoma containing fibroblast osteosarcoma: clinicopathological analysis and literat
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CASE REPORT
Primary meningeal osteoblastic osteosarcoma containing fibroblast osteosarcoma: clinicopathological analysis and literature review Y. Q. Qiu 1 & Y. L. Chen 1 Received: 28 August 2020 / Accepted: 6 October 2020 # International Osteoporosis Foundation and National Osteoporosis Foundation 2020
Abstract Primary meningeal osteosarcoma is rare. The aim of this report is to investigate the symptoms, imaging data, pathological diagnosis, and treatment of primary meningeal osteosarcoma. A 54-year-old male patient was admitted to hospital because of numbness and weakness in the right limb, accompanied by dizziness and chest tightness. The CT and MRI examination of the patient showed multiple irregular mixed density mass signal shadows. After preliminary examinations and tests, meningioma was considered. After surgical resection, the mass was sent for pathological examination, and primary meningeal osteosarcoma was finally diagnosed. The patient did not receive radiotherapy and chemotherapy and died 7 months later. Primary meningeal osteosarcoma is a rare and easily misdiagnosed disease. There is no test that is specific enough up to now, so the correct diagnosis can only be determined by a histopathological examination. At present, there are no clear drug, radiotherapy, and chemotherapy guidelines for the treatment of this disease in addition to surgery, and the prognosis is poor. Keywords Clinicopathological analysis . Fibroblast osteosarcoma . Primary meningeal osteosarcoma
Introduction Primary osteosarcoma is a highly malignant tumor derived from bone tissue with about 80–90% of primary osteosarcoma occurring in long bones. Epidemiological studies have found that primary osteosarcoma is common in teenagers aged 10–19. However, among patients over 40 years old, the generation of primary osteosarcoma needs inducing factors, such as radiation exposure, bone Paget’s disease, or fibrous dysplasia. Without inducing factors, the incidence rates of osteosarcoma of skull and osteosarcoma of meninges are extremely rare. According to the classification in the new edition of the WHO pathology and genetics of soft tissue and bone tumors, primary meningeal
osteosarcoma is one subtype of extra-skeletal osteosarcoma. The first reported primary meningeal osteosarcoma in 1941 was by Turner [1], and merely 12 cases have been reported in relevant literatures [1–12]. Of the 12 cases, there are three cases with histopathological classification, two cases of chondrogenic osteosarcoma [7, 11], and one case of fibroblast osteosarcoma [6]. Therefore, the understanding of primary meningeal osteosarcoma is not enough. In this paper, we report a case of primary meningeal osteoblastic osteosarcoma containing components of fibroblastic osteosarcoma and discuss the clinical and imaging manifestations, pathological features, and differential diagnosis and treatment.
Case report Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00198-020-05675-8) contains supplementary material, which is availa
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