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Diego Preciado Editor

Otitis Media: State of the Art Concepts and Treatment

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Editor Diego Preciado Department of Pediatric Otolaryngology Children’s National Medical Center Washington District of Columbia USA

ISBN 978-3-319-17887-5     ISBN 978-3-319-17888-2 (eBook) DOI 10.1007/978-3-319-17888-2 Library of Congress Control Number: 201594228 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer is a brand of Springer International Publishing Springer International Publishing is part of Springer Science+Business Media (www.springer.com)

Contents

Part I  Introduction 1  Otitis Media Concepts, Facts, and Fallacies���������������������������������    3 Diego Preciado Part II  Concepts and Diagnosis 2 Epidemiology of Otitis Media: What Have We Learned from the New Century Global Health Disparities�����������������������  13 Ricardo Godinho and Tania Sih 3 Impact of Genetic Background in Otitis Media Predisposition����������������������������������������������������������������������  17 Shannon Fraser, J. Christopher Post and Margaretha L. Casselbrant 4 Risk Factors for Recurrent Acute Otitis Media and Chronic Otitis Media with Effusion in Childhood���������������  23 José Faibes Lubianca Neto and Tania Sih 5 Microbiology, Antimicrobial Susceptibility, and Antibiotic Treatment�����������������������������������������������������������������������  33 Tania Sih and Rita Krumenaur 6  Abnormal Innate and Adaptive Immunity in Otitis Media��������  47 Jizhen Lin 7 Basic Science Concepts in Otitis Media Pathophysiology and Immunity: Role of Mucins and Inflammation����������������������  53 Stéphanie Val 8  Diagnosis of Otitis Media���������������������������������������������������������������  79 Christopher R. Grindle

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Part III  Treatments 9 Treatment: Impact of Vaccination and Progress in Vaccine Development���������