Ovarian ependymoma presenting in pregnancy: a case report and literature review
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CASE REPORT
Open Access
Ovarian ependymoma presenting in pregnancy: a case report and literature review Bo Jin1, Jingjing Jiang2 and Hongfa Peng1*
Abstract Background: Ovarian ependymoma is a rare malignancy. Because of the extreme rarity, certain features of the neoplasm, including its clinical behaviour and optimal therapy, are incompletely characterized. Case presentation: A 32-year-old pregnant woman at term presented with a left ovarian neoplasm that occurred in the early stage of pregnancy. She underwent left adnexectomy during the caesarean section, and the neoplasm was histologically and immunohistochemically identified to be ovarian ependymoma. Immunohistochemical staining with oestrogen receptors and progesterone receptors showed strong positive staining. According to reports in the literature, the pathological type of ovarian ependymoma in our patient was the extra-axial type. Interestingly, the foetus was also found to have bilateral ependymal cysts during pregnancy. The patient received no further surgical treatment or adjuvant therapy. She and her 14-month-old baby both have no evidence of disease at present. The follow-up of both mother and child is still continuing. Conclusions: The case presented here illustrates high levels of oestrogen during pregnancy may stimulate viable malignant ependymal cells to proliferate. Hence, young women with extra-axial-type ependymomas may not be suitable for fertility preservation. Moreover, hormone-based therapies can be a potentially effective treatment for women with extra-axial ependymomas. Keywords: Ovarian ependymoma, Oestrogen, Pregnancy, Hormone-based therapies, Case report
Background Ovarian ependymoma is an extremely rare gynaecologic malignancy that poses numerous diagnostic and treatment challenges. Because of the extreme rarity, certain features of the neoplasm, including the clinical behaviour, molecular profile, and optimal therapy, are incompletely characterized. Herein, we present a case of primary ependymoma of the ovary that appeared after pregnancy and grew gradually during pregnancy as well as a summary of primary ovarian ependymomas based * Correspondence: [email protected] 1 Department of Obstetrics and Gynecology, Second hospital of Hebei medical university, Heping West Road No. 215, Hebei province 050000 Shijiazhuang City, China Full list of author information is available at the end of the article
on a review of all such cases published in the English literature.
Case presentation A 32-year-old woman (gravid 2,para 1) at term presented at our institution with a mass on her left ovary and previous caesarean section requiring a caesarean section. Her general medical and gynaecologic histories were unremarkable. In 2015, she had a caesarean section because of a foetal diaphragmatic hernia. Prior to this pregnancy, both gynaecological examination and transvaginal ultrasonography were negative. Transvaginal ultrasonography revealed an anechoic cyst in the left adnexal region at 45 days pregnant, with a size of approximately 2.6*2.4 cm
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