Overexpression of IL-17RC associated with ocular sarcoidosis
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RESEARCH
Open Access
Overexpression of IL-17RC associated with ocular sarcoidosis Wenting Wu1,2,3, Ming Jin3, Yujuan Wang1,4, Baoying Liu1, Defen Shen1, Ping Chen1, Susan Hannes1, Zhiyu Li1, Sima Hirani1, Shayma Jawad1, UNITE Human Ocular Inflammation Consortium, H Nida Sen1, Chi-Chao Chan1, Robert B Nussenblatt1* and Lai Wei1,4*
Abstract Background: Sarcoidosis is a chronic inflammatory disease with a systemic granulomatous disorder affecting multiple organs including the eye. Both CD4+ T cell and macrophage have been linked to the pathogenesis of the disease. Methods: The expression of IL-17RC was measured using FACS,immunohistochemistry and real-time PCR. Serum level of IL-17 was detected using ELISA. Results: An elevated expression of IL-17RC on CD8+ T cells in peripheral blood was found in patients with ocular sarcoidosis as compared to healthy controls. Interestingly, we found a significant increase in the serum level of IL-17 in patients with ocular sarcoidosis as compared to healthy controls, which may be responsible for the induction of IL-17RC on CD8+ cells. In addition, IL-17RC appeared only in the retinal tissue of the patient with clinically active sarcoidosis. Conclusions: Our results suggested a potential involvement of IL-17RC+CD8+ T cells in pathogenesis of ocular sarcoidosis. Keywords: Ocular sarcoidosis, IL-17RC, CD8
Background Sarcoidosis is a systemic granulomatous disorder affecting multiple organs. Chronic inflammation occurs predominantly in the lung. In addition, lymph node, gastrointestinal tract, skin, nervous system, liver, spleen, heart, kidney, and muscle can also be affected. Ocular involvement is found in 25-50% patients with sarcoidosis and can be the first clinical manifestation of the disease according to several American and European studies [1,2]. However, ocular involvement may be found in up to 89% of Japanese patients with systemic sarcoidosis, suggesting a potential racial difference of its clinical presentation. Ocular sarcoidosis can occur in the absence of other systemic manifestations. Although the diagnosis of sarcoidosis can be confirmed by biopsy of the skin, conjunctiva, peripheral lymph nodes, or lung, the etiology of sarcoid granulomas is unknown [1]. * Correspondence: [email protected]; [email protected] 1 Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA 4 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Full list of author information is available at the end of the article
Recent studies suggest sarcoidosis susceptibility is dependent on both genetic and environmental risk factors [3]. All races can suffer from sarcoidosis. Aggregation among certain racial/ethnic groups [4], as well as increased concordance among monozygotic twins [5] both strongly support the probability of a genetic susceptibility to sarcoidosis. Recent case–control genetic studies and genome-wide association studies (GWAS) identified multiple single nucleotide polymorph
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