Overhydration and low serum prealbumin predict peritoneal dialysis-related peritonitis in continuous ambulatory peritone
- PDF / 1,070,188 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 85 Downloads / 157 Views
RESEARCH ARTICLE
Open Access
Overhydration and low serum prealbumin predict peritoneal dialysis-related peritonitis in continuous ambulatory peritoneal dialysis patients Quyen Dao Bui Quy1, Tuan Pham Ngoc Huy2, Loc Nguyen Duc3, My Pham Van4, Dung Nguyen Huu5, Toan Nguyen Duy6,7, Tien Tran Viet6,7, Quyet Do7 and Thang Le Viet6,7*
Abstract Background: In this study, we focused on the role of overhydration (OH) and low serum prealbumin concentration in predicting peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 3-year period. Methods: We measured serum prealbumin concentration and OH by body composition monitor in 278 CAPD patients (159 males and 119 females) with a mean age of 46 years and a median peritoneal dialysis (PD) duration of 21 months. Cases of PD-related peritonitis were collected over 3 years. Results: After the 3-year follow-up, 44 patients were diagnosed with PD-related peritonitis (15.8%). Low education, serum glucose, prealbumin, and OH were independent risk factors for predicting peritonitis over 36 months in CAPD patients. Based on the ROC curve model and Kaplan-Meier analysis, we realized that low prealbumin and high OH were independent predictors of 3-year peritonitis in CAPD patients (Prealbumin: AUC = 0.838, cut-off value = 32.5 mg/dL, Se = 90.9%, Sp = 32.9%; OH: AUC = 0.851, cut-off value = 1.33 L, Se = 79.5%, Sp = 85.5%; and logrank test p < 0.001, respectively). Conclusion: Overhydration and low serum prealbumin were the independent predictors of PD-related peritonitis in CAPD patients. Keywords: Continuous ambulatory peritoneal dialysis, Overhydration, Serum prealbumin, Peritoneal dialysis, Peritonitis
Background Peritoneal dialysis (PD) is a renal replacement therapy based on infusing a sterile solution into the peritoneal cavity through a catheter, and it provides for the removal of solutes and water using the peritoneal membrane as the exchange surface [1–3]. Infusion and drainage of the * Correspondence: [email protected] 6 Military Hospital 103, Ha Noi, Viet Nam 7 Vietnam Military Medical University, Ha Noi, Viet Nam Full list of author information is available at the end of the article
solution into the peritoneal cavity can be performed in two ways: manually (continuous ambulatory PD) or machine-assisted PD (automated PD) [1, 2]. Peritonitis is a common serious complication of peritoneal dialysis that results in considerable morbidity, mortality, and health care costs [4–6]. Depending on the underlying causative agent, PD-related peritonitis is complicated by relapse in 3–20% (14% overall), catheter removal in 10–88% (22% overall), and permanent HD transfer in 9–74% (18% overall) of cases [7, 8]. After a single episode of peritonitis, the risks of death due to infection and cardiovascular
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit t
Data Loading...
