Oxidative stress and its association with ST resolution and clinical outcome measures in patients with ST-segment elevat
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BMC Research Notes Open Access
RESEARCH NOTE
Oxidative stress and its association with ST resolution and clinical outcome measures in patients with ST‑segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention Elmira Matin1, Samad Ghaffari1*, Alireza Garjani2, Neda Roshanravan1, Somaieh Matin3, Naimeh Mesri Alamdari1,4 and Naser Safaie1
Abstract Objective: Reperfusion of ischemic myocardium generates oxidative stress, which itself can mediate myocardial injury. So, in this study, we investigated the level of oxidative stress markers and its association with clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Results: As indicated in the results, Post MI (Myocardial Infarction) heart failure was significantly higher in the group A (11% vs 4%, p = 0.047). Complete STR (ST-segment resolution) was observed to be significantly higher in the group B (36% vs 17%, p = 0.006). The SOD (Superoxide dismutase) and GPX (Glutathione peroxidase) levels were significantly higher in the group B compared to the other group (1547.51 ± 328.29 vs. 1449.97 ± 246.06, p = 0.019 and 60.62 ± 11.95 vs 57.41 ± 10.14, p = 0.042). The levels of GPX and SOD were shown to be directly related with complete STR and post PCI (Percutaneous coronary intervention)TIMI(Thrombolysis in Myocardial Infarction) flow 3 in the group A (p = 0.002 and p 0.05 (NS)
Smoking, n (%)
35 (35)
33 (33)
p > 0.05 (NS)
Family history, n (%)
32 (32)
27 (27)
p > 0.05 (NS)
Anterior STEMI, n (%)
61 (61)
56 (56)
p > 0.05 (NS)
Lateral STEMI, n (%)
5 (5)
6 (6)
p > 0.05 (NS)
Inferior RV STEMI, n (%)
9 (9)
15 (15)
p > 0.05 (NS)
Inferior STEMI, n (%)
25 (25)
23 (23)
p > 0.05 (NS)
NS, not significant, Group A: TIMI flow < 2, Group B: TIMI flow ≥ 2
*p-value was reported based on Chi-Square test & Independent sample t test
Table 2 The average serum levels of biochemical factors in group A and B (mean ± SD) Variable
Group A (n = 100)
Group B (n = 100)
p-value
MDA (nmol/ml)
2.33 ± 0.76
2.22 ± 0.82
0.133
TAC (mmol/l)
1.73 ± 0.4
1.65 ± 0.4
0.322
SOD (µ/g Hb)
1449.97 ± 246.06
1547.51 ± 328.29
0.019*
GPX (µ/g Hb)
57.41 ± 10.14
60.62 ± 11.95
0.042*
SD: standard deviation, SOD: superoxide dismutase, GPX: Glutathione Peroxidase, MDA: Malondialdehyde, TAC: Total anti-oxidant capacity *p
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