Oxidative Stress in Human Reproduction Shedding Light on a Complicat

This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the hum

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Oxidative Stress in Human Reproduction

Ashok Agarwal • Rakesh Sharma • Sajal Gupta Avi Harlev • Gulfam Ahmad Stefan S. du Plessis  •  Sandro C. Esteves Siew May Wang  •  Damayanthi Durairajanayagam Editors

Oxidative Stress in Human Reproduction Shedding Light on a Complicated Phenomenon

Editors Ashok Agarwal American Center for Reproductive Medicine Cleveland Clinic Cleveland, OH, USA Sajal Gupta American Center for Reproductive Medicine Cleveland Clinic Cleveland, OH, USA Gulfam Ahmad College of Medicine Prince Sattam Bin Abdulaziz University Al Kharj, KSA, Saudi Arabia Department of Physiology University of Health Sciences Lahore, Pakistan Sandro C. Esteves Androfert Referral Center for Male Reproduction Campinas, São Paulo, Brazil

Rakesh Sharma American Center for Reproductive Medicine Cleveland Clinic Cleveland, OH, USA Avi Harlev Department of Obstetrics & Gynecology F-IVF Soroka University Medical Center Ben-Gurion University of the Negev Sansana, Israel Stefan S. du Plessis Division of Medical Physiology Stellenbosch University Tygerberg, South Africa Siew May Wang American Center for Reproductive Medicine Cleveland Clinic Cleveland, OH, USA

Damayanthi Durairajanayagam Faculty of Medicine Universiti Teknologi MARA Sungai Buloh, Selangor, Malaysia ISBN 978-3-319-48425-9    ISBN 978-3-319-48427-3 (eBook) DOI 10.1007/978-3-319-48427-3 Library of Congress Control Number: 2017936214 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Foreword

Since the introduction of the concept of “oxidative stress” introduced into redox biology and medicine and coining of the term by Helmut Sies more tha