Epigenetics and Human Reproduction
Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clea
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Sophie Rousseaux Saadi Khochbin Editors
Epigenetics and Human Reproduction
Epigenetics and Human Health
Series Editors Prof. Dr. Robert Feil Institute of Molecular Genetics CNRS and University of Montpellier 1919 route de Mende 34293 Montpellier Cedex 5 France Prof. Dr. Jo¨rn Walter Universita¨t des Saarlandes Naturwissenschaftlich-Technische Fakulta¨t III FR 8.3 Biowissenschaften/Genetik/Epigenetik Postfach 151150 66041 Saarbru¨cken Germany
Associate Editor Dr. Mario-Noyer-Weidner Schwa¨bische Str. 3 10781 Berlin Germany
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Sophie Rousseaux Saadi Khochbin l
Editors
Epigenetics and Human Reproduction
Editors Sophie Rousseaux and Saadi Khochbin Institut Albert Bonniot. Centre de Recherche INSERM/ Universite´ Joseph Fourier U823 Labo. Epigenetics & Cell Signalling. 38706 La Tronche CX Domaine de la Merci France [email protected]; [email protected]
ISBN 978-3-642-14772-2 e-ISBN 978-3-642-14773-9 DOI 10.1007/978-3-642-14773-9 Springer Heidelberg Dordrecht London New York # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface to the Series
“Epigenetics and Human Reproduction” is the first volume of a new Springer book series on epigenetics and human health and covers various aspects of human reproduction in relation to epigenetic reprogramming during female and male gametogenesis. Drs. Saadi Khochbin and Sophie Rousseaux, the volume Editors of “Epigenetics and Human Reproduction”, are specialists in this biomedical field. They both direct research programmes at the Albert Bonniot Institute in Grenoble (France), one of the centres in the epigenetics of reproduction in Europe. Combined, their expertise goes from fundamental studies using cells and animal models to the understanding and clinical follow-up of infertility in humans. This broad understanding of chromatin and epigenetics in reproduction was most beneficial to the balanced choice of the 15 chapters, each of which covers a different aspect of this emerging field. In fact, this comprehensively referenced book is the first one of its kind. It will be of considerable interest not only to clinicians and
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