Pain Control
This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechan
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Hans-Georg Schaible Editor
Pain Control
Handbook of Experimental Pharmacology
Volume 227 Editor-in-Chief W. Rosenthal, Jena
Editorial Board J.E. Barrett, Philadelphia V. Flockerzi, Homburg M.A. Frohman, Stony Brook, NY P. Geppetti, Florence F.B. Hofmann, Mu¨nchen M.C. Michel, Ingelheim P. Moore, Singapore C.P. Page, London A.M. Thorburn, Aurora, CO K. Wang, Beijing
More information about this series at http://www.springer.com/series/164
Hans-Georg Schaible Editor
Pain Control
Editor Hans-Georg Schaible Jena University Hospital Institute of Physiology/Neurophysiology Jena Thu¨ringen Germany
ISSN 0171-2004 ISSN 1865-0325 (electronic) Handbook of Experimental Pharmacology ISBN 978-3-662-46449-6 ISBN 978-3-662-46450-2 (eBook) DOI 10.1007/978-3-662-46450-2 Library of Congress Control Number: 2015936907 Springer Heidelberg New York Dordrecht London # Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag GmbH Berlin Heidelberg is part of Springer Science+Business Media (www.springer.com)
Preface
Current pain treatment is successful in many patients, but nevertheless numerous problems have to be solved because still about 20 % of the people in the population suffer from chronic pain. A major aim of pain research is, therefore, to clarify the neuronal mechanisms which are involved in the generation and maintenance of different pain states, and to identify the mechanisms which can be targeted for pain treatment. This volume on pain control addresses neuronal pain mechanisms at the peripheral, spinal, and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in
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