Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical mode
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Christophe Le Tourneau Maud Kamal Editors
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Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
Christophe Le Tourneau • Maud Kamal Editors
Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine
Editors Christophe Le Tourneau Institut Curie Department of Medical Oncology Saint-Cloud, Paris France
Maud Kamal Institut Curie Department of Medical Oncology Saint-Cloud, Paris France
ISBN 978-3-319-22188-5 ISBN 978-3-319-22189-2 DOI 10.1007/978-3-319-22189-2
(eBook)
Library of Congress Control Number: 2015949934 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Contents
1
Introduction: Rationale for Precision Medicine Clinical Trials . . . . . . . 1 Christophe Le Tourneau
2
The Key Role of Pathology in the Context of Precision Medicine Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Anne Vincent-Salomon
3
Basis for Molecular Genetics in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . 15 Gaëlle Pierron
4
Microarrays-Based Molecular Profiling to Identify Genomic Alterations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 David Gentien and Cecile Reyes
5
High-Throughput Technologies: DNA and RNA Sequencing Strategies and Potential . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Thomas Rio Frio
6
Bioinformatics for Precision Medicine in Oncology . . . . . . . . . . . . . . . 69 Nicolas Servant and Philippe Hupé
7
Assessment of Biomarkers’ Predictive Value of Efficacy . . . . . . . . . . 101 Etienne Rouleau, Céline Callens, Gaëlle Pierron, and Ivan Bièche
8
Designs for Evaluating Precision Medicine Trials . . . . . . . . . . . . . . . . 113 Xavier Paoletti, Bernard
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