Parent-reported cognitive function is associated with leukoencephalopathy in children with brain tumors
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Parent-reported cognitive function is associated with leukoencephalopathy in children with brain tumors Jin-Shei Lai1 • Corey Bregman2 • Frank Zelko3 • Cindy Nowinski4 David Cella4 • Jennifer J. Beaumont4 • Stewart Goldman5
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Accepted: 21 March 2017 Ó Springer International Publishing Switzerland 2017
Abstract Purpose Cognitive dysfunction is a major concern for children with brain tumors. A valid, user-friendly screening tool could facilitate prompt referral for comprehensive neuropsychological assessments and therefore early intervention. Applications of the pediatric perceived cognitive function item bank (pedsPCF) such as computerized adaptive testing can potentially serve as such a tool given its brevity and user-friendly nature. This study aimed to evaluate whether pedsPCF was a valid indicator of cerebral compromise using the criterion of structural brain changes indicated by leukoencephalopathy grades. Methods Data from 99 children (mean age = 12.6 years) with brain tumors and their parents were analyzed. Average time since diagnosis was 5.8 years; time since last treatment was 4.3 years. Leukoencephalopathy grade (range 0–4) was based on white matter damage and degree of deep white matter volume loss shown on MRI. Parents of patients completed the pedsPCF. Scores were based on the
US general population-based T-score metric (mean = 50; SD = 10). Higher scores reflect better function. Results Leukoencephalopathy grade distributions were as follows: 36 grade 0, 27 grade 1, 22 grade 2, 13 grade 3, and 1 grade 4. The mean pedsPCF T-score was 48.3 (SD = 8.3; range 30.5–63.7). The pedsPCF scores significantly discriminated patients with different leukoencephalopathy grades, F = 4.14, p = 0.0084. Effect sizes ranged from 0.09 (grade 0 vs. 1) to 1.22 (grade 0 vs. 3/4). Conclusion This study demonstrates that the pedsPCF is a valid indicator of leukoencephalopathy and provides support for its use as a screening tool for more comprehensive neurocognitive testing.
& Jin-Shei Lai [email protected]
1
Corey Bregman [email protected]
Medical Social Sciences and Pediatrics, Feinberg School of Medicine at Northwestern University, 633 N St Clair, #19039, Chicago, IL 60611, USA
2
Frank Zelko [email protected]
Medical Imaging (Radiology), Ann & Robert H. Lurie Children’s Hospital, Chicago, IL 60611, USA
3
Pediatric Neuropsychology Service, Department of Child and Adolescent Psychiatry, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA
4
Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
5
Hematology/Oncology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA
Keywords Brain tumor Pediatrics Leukoencephalopathy Perceived cognitive function Patient-centered outcome
Cindy Nowinski [email protected] David Cella [email protected] Jennifer J. Beaumont [email protected] Stewart Goldman [email protected]
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Qual Life Res
Introduction Brain
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