Patient Benefit-Risk Preferences for Targeted Agents in the Treatment of Renal Cell Carcinoma
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Pharmacoeconomics 2011; 29 (11): 977-988 1170-7690/11/0011-0977/$49.95/0
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Patient Benefit-Risk Preferences for Targeted Agents in the Treatment of Renal Cell Carcinoma Ateesha F. Mohamed,1 A. Brett Hauber1 and Maureen P. Neary 2 1 RTI Health Solutions, Research Triangle Park, NC, USA 2 GlaxoSmithKline, Collegeville, PA, USA
Abstract
Background: Angiogenesis inhibitor agents have been shown to be effective in increasing progression-free survival (PFS) in patients with renal cell carcinoma (RCC); however, these treatments have different toxicity profiles. Objective: Our objective was to quantify patients’ benefit-risk preferences for RCC treatments and relative importance of attributes in a common metric. Methods: US residents aged ‡18 years with RCC completed a web-enabled, choice-format conjoint survey that presented a series of 12 trade-off questions, each including a pair of hypothetical RCC treatment profiles. Each profile was defined by efficacy (PFS, when overall survival held constant), tolerability effects (fatigue/tiredness, diarrhoea, hand-foot syndrome [HFS], mouth sores) and serious adverse events (liver failure, blood clot). Trade-off questions were based on a predetermined experimental design with known statistical properties. Random-parameters logit was used to analyse the data. Results: A total of 138 patients completed the survey. PFS was the most important attribute for patients over the range of levels included in the survey, while remaining attributes were ranked in decreasing order of importance: fatigue/tiredness, diarrhoea, liver failure, HFS, blood clot and mouth sores. In order to increase PFS by 11 months, patients would be willing to accept a maximum level of absolute blood clot risk of 3.1% (95% CI 1.5, 5.3) or liver failure risk of 2.0% (95% CI 1.0, 3.3). Conclusion: A 22-month change in PFS was shown to be the most important improvement for patients. Severe fatigue/tiredness and diarrhoea were rated as the most troublesome tolerability effects of RCC treatment. Patients were likely willing to accept significant treatment-related risks of 2–3% for liver failure and blood clot to increase PFS by 11 months.
Mohamed et al.
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Key points for decision makers Progression-free survival (PFS) was the most important treatment outcome to patients when making treatment decisions Severe fatigue and severe diarrhoea were the most troublesome tolerability effects Patients were willing to accept small liver failure and blood clot risks in exchange for additional months of PFS
Background Renal cell carcinoma (RCC) occurs when cancerous cells form in the renal tubular epithelium. RCC is the most common type of kidney cancer,[1] with 25–30% of patients with metastatic disease at diagnosis.[1-4] According to the National Cancer Institute, the estimated number of new cases of RCC in the US in 2010 is approximately 58 000.[5] Pharmaceutical treatment options for RCC include cytokines (interferon [IFN]-a and interleukin-2), angiogenesis inhi
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