Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer
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ORIGINAL ARTICLE
Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer Sarah Nicole Hamilton 1,2 & Eric Tran 1,2 & Cheryl Ho 1,2 & Eric Berthelet 1,2 & Jonn Wu 1,2 & Kimberly DeVries 1 & Vincent LaPointe 1 & Angela Bowman 1 & Minette Lagman 1 & Robert Olson 2,3,4 Received: 17 April 2020 / Accepted: 11 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objectives Head and neck (H&N) cancer patients experience significant acute side effects from treatment. This study evaluates prospectively collected patient-reported outcomes (PROs) in H&N patients undergoing radiotherapy (RT) to assess feasibility of electronically collecting PROs and to objectively document symptom acuity and trajectory during RT. Materials and methods H&N patients undergoing radical RT at our multicentre institution completed a 12-item partial survey of the Vanderbilt Head & Neck Symptom Survey 2.0 prior to RT and weekly on RT. Between October 2016 and October 2018, 318 of 333 patients completed a baseline survey and at least one weekly survey. Results The average number of weekly questionnaires completed was 5 (range 1–8). The mean maximum symptom scores were highest for dysgeusia (5.8/10), pain (5.4/10), mucositis (4.8/10), weight loss due to swallowing (4.5/10) and mucus causing choking/gagging (4.3/10). On multivariate analysis, female gender, sinonasal, nasopharynx and oropharynx primaries were associated with a greater risk of moderate-severe pain (p < 0.05). Sinonasal, nasopharynx, oral cavity, oropharynx and thyroid primaries were associated with a greater risk of moderate-severe mucositis during radiation (p < 0.0001). Salivary gland, sinonasal, nasopharynx and oropharynx primaries and higher radiation dose were associated with a greater risk of moderatesevere dysgeusia (all p < 0.05). Conclusions Electronic PRO collection during H&N cancer RT is feasible. H&N cancer patients experience significant symptoms during RT, and the most severe symptoms reported were dysgeusia, pain and mucositis. Oropharynx cancer patients reported the highest symptom scores during RT. Keywords Patient-reported outcomes . Head and neck cancer . Radiation treatment side effects . Radiotherapy . Quality of life . Supportive care
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00520-020-05778-2) contains supplementary material, which is available to authorized users. * Sarah Nicole Hamilton [email protected] 1
BC Cancer - Vancouver Centre, 600 W 10th Ave, Vancouver, BC V5K 4E6, Canada
2
Univeristy of British Columbia, Vancouver, BC, Canada
3
BC Cancer - Centre for the North, Prince George, BC, Canada
4
University of Northern British Columbia, Prince George, BC, Canada
Radiotherapy (RT), as primary curative or adjuvant therapy, is commonly used for the treatment of head and neck (H&N) cancer. Radical RT is associated with significant acute toxicity including severe xerostomia, dysphagia, odynophagia, pain, thicke
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