Pattern Recognition Receptors and Aging

Pattern recognition receptors (PRRs), such as the toll-like receptors (TLRs), C-type lectin receptors (CLRs), nucleotide-binding oligomerization domain and leucine-rich repeat-containing receptors (NLRs), and the more recently discovered cytosolic RNA- an

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Immunology of Aging

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Immunology of Aging

Ahmad Massoud • Nima Rezaei Editors

Immunology of Aging

Editors Ahmad Massoud, PharmD, MPH, PhD Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran

Nima Rezaei, MD, MSc, PhD Research Center for Immunodeficiencies Children’s Medical Center Hospital Tehran Iran Department of Immunology School of Medicine Molecular Immunology Research Center Tehran University of Medical Sciences Tehran Iran

ISBN 978-3-642-39494-2 ISBN 978-3-642-39495-9 DOI 10.1007/978-3-642-39495-9 Springer Heidelberg New York Dordrecht London

(eBook)

Library of Congress Control Number: 2013954848 © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Foreword

The rapidity of scientific progress over the last few years emphasizes the utility of a new collection of state-of-the-art reviews on the immunology of aging, as edited here by Drs Massoud and Rezaei. They have succeeded in putting together a remarkable set of contributions from many well-known scientists in the immunosenescence research field. Because the number of elderly people is increasing, both in the rich world and in developing countries, aging is a huge challenge for society globally and for the science o