Recognition Receptors in Biosensors
This book presents a significant and up-to-date review of various recognition receptors, their immobilization, and an overview of surface characterization techniques. Distinguished scientists from key institutions worldwide have contributed chapters that
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Recognition Receptors in Biosensors
Recognition Receptors in Biosensors
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Mohammed Zourob Editor
Recognition Receptors in Biosensors
Editor Dr. Mohammed Zourob GDG ENVIRONNEMENT LTE´E 430, rue Saint-Laurent, 2e e´tage Trois-Rivie`res (Quebec), Canada G8T 6H3 [email protected]
Professor at:
Institut national de la recherche scientifique Center- E´nergie, Mate´riaux et Te´le´communications 1650, boul. Lionel-Boulet Varennes (Que´bec) Canada J3X 1S2 [email protected]
ISBN: 978-1-4419-0918-3 e-ISBN: 978-1-4419-0919-0 DOI 10.1007/978-1-4419-0919-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009930469 # Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent specific binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to induction and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in specific and desired ways. This book presents a significant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of distinguished scientists. This work is a comprehensive approach to the recognition receptors area pre
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