Patterned Nanoparticle Assembly as Novel Chemical and Biological Platforms
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Patterned Nanoparticle Assembly as Novel Chemical and Biological Platforms M.M. Maye, J. Luo, L. Han, N. Kariuki, F.X. Zhang, C.J. Zhong * Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902. (*) [email protected]
ABSTRACT The ability to self-assemble nanoparticles into thin films and subsequently characterize the structural or morphological responses to interfacial chemical/biological reactivity is increasingly important. Surface patterning and tailoring us ing nanoparticle assemblies are expected to provide such abilities for selective immobilization and chemical and biological recognition. We describe herein recent results of an investigation of hydrogen-bonding based self-assembly of core-shell nanoparticles onto monolayer-patterned surfaces, and its potential utility for in-situ atomic force microscopic characterizations of interfacial chemical and biological reactivities. This system is potentially useful for immunoassays based on topographical height changes with well-defined internal morphological standard. INTRODUCTION Monolayer-capped metal nanoparticles ("core-shell nanoparticles") have emerged as an interesting class of composite nanoparticles that has potential applications in chemical and bio logical sensing, drug delivery, immunoassays, information technologies, filtration, and catalysis [1]. These nanomaterials can be synthesized [2] and further processed into monodispersed sizes [3]. When gold nanoparticles are self-assembled with the use of a molecular crosslinking agent, either via a stepwise method [4] or onestep method [5], functional properties are expected from the nanostructured shell-core and shell-shell chemistries [6-7]. On the basis of recent insights into such nanostructured properties [1] we have recently developed an exchange-crosslinking-precipitation route towards the assembly of alkanethiolate-capped gold nanoparticles into thin films [5-6]. The films serve as effective means for the creation of nanostructures that can sense changes in their chemical environment or are catalytically active [8]. Probing the interfacial reactivities of such nanostructured thin films is thus interesting. Surface patterning using various monolayer structures is of recent interest for developing imaging approaches to detecting biological agents. Porter and co-workers recently demonstrated an analytical method which uses patterned self-assembled monolayers for selective immobilization of antigen and antibody, and utilize scanning force microscopy to image the associated height changes [9]. We describe herein recent infrared reflection spectroscopic (IRS) and atomic force microscopic (AFM) results of an investigation of the nanoparticle assembly and the interfacial chemistry at nanoparticle-patterned surfaces, which are potentially useful for immunoassay applications.
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EXPERIMENT Synthesis and Processing. Gold nanoparticles of 5 nm core size (Au5-nm) used in this study were produced by thermally-activated processing of pre-synthesized gold nanoparticles
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