Peculiarities of the Expression of Inducible NO Synthase in Rat Dentate Gyrus in Depression Modeling
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Bulletin of Experimental Biology and Medicine, Vol. 169, No. 5, September, 2020 MORPHOLOGY AND PATHOMORPHOLOGY
Peculiarities of the Expression of Inducible NO Synthase in Rat Dentate Gyrus in Depression Modeling
M. R. Ekova1, A. V. Smirnov1,2, I. N. Tyurenkov1, and N. V. Grigor’eva1 Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 653-656, May, 2020 Original article submitted December 10, 2019 Mild stress exposure contributes to the development of cognitive and emotional deficits, is considered as a model of depressive state, and is characterized by enhanced NO production. In albino mature (12-month-old) male rats, the depressive state was simulated by daily 30-min exposure to stressful stimuli (vibration, loud sound, and strobe light) over 7 days in a special chamber. On paraffin frontal sections of the brain stained with antibodies against inducible NO synthase (iNOS), the expression and distribution pattern of immunoreactive material were evaluated in various layers of the dentate gyrus under normal conditions and after depression modeling. The relative area of iNOS expression in the dentate gyrus of control rats was 8.2 (7.19.9)%, while in rats with experimental depression, this parameter was 16.7 (10.5-22.1)%, i.e. increased by 8.5% (p
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