Pediatric neurodevelopment by prenatal Zika virus exposure: a cross-sectional study of the Microcephaly Epidemic Researc
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RESEARCH ARTICLE
Open Access
Pediatric neurodevelopment by prenatal Zika virus exposure: a cross-sectional study of the Microcephaly Epidemic Research Group Cohort Paula Fabiana Sobral da Silva1*, Sophie Helena Eickmann2, Ricardo Arraes de Alencar Ximenes1,2, Ulisses Ramos Montarroyos1, Marilia de Carvalho Lima2, Celina M. Turchi Martelli3, Thalia Velho Barreto de Araújo2, Elizabeth B. Brickley4, Laura Cunha Rodrigues4, Fabiana Cristina Lima da Silva Pastich Gonçalves2, Maria Durce Costa Gomes Carvalho1, Wayner Vieira de Souza3 and Demócrito de Barros Miranda-Filho1
Abstract Background: The implications of congenital Zika Virus (ZIKV) infections for pediatric neurodevelopment and behavior remain inadequately studied. The aim of this study is to investigate patterns of neurodevelopment and behavior in groups of children with differening severities of ZIKV-related microcephaly and children with prenatal ZIKV exposure in the absence of microcephaly. Methods: We conducted a cross-sectional study, nested in a cohort, of 274 children (aged 10–45 months) who were born during the peak and decline of the microcephaly epidemic in Northeast Brazil. Participants were evaluated between February 2017 and August 2019 at two tertiary care hospitals in Recife, Pernambuco, Brazil. We analyzed the children in four groups assigned based on clinical and laboratory criteria: Group 1 had severe microcephaly; Group 2 had moderate microcephaly; Group 3 had prenatal ZIKVexposure confirmed by maternal RTPCR testing but no microcephaly; and Group 4 was a neurotypical control group. Groups were evaluated clinically for neurological abnormalities and compared using the Survey of Wellbeing of Young Children (SWYC), a neurodevelopment and behavior screening instrument validated for use in Brazil. Children with severe delays underwent further evaluation with an adapted version of the SWYC. (Continued on next page)
* Correspondence: [email protected] 1 Hospital Universitário Oswaldo Cruz, Recife, Brasil Full list of author information is available at the end of the article
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