Pembrolizumab
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Sarcoid‐like reaction: case report A 55-year-old man developed sarcoid‐like reaction during treatment with pembrolizumab for metastatic non‐small cell lung cancer. The man presented with a new infiltrates in the left lower lung lobe following 4 months of pembrolizumab [route and dosage not stated] therapy for non-mutated, metastatic non‐small cell lung cancer. Initially, tumour recurrence was considered. Subsequently, he underwent transbronchial lung biopsy which showed non‐caseating granulomas in the bronchial mucosa. Ziehl‐Neelsen stain for acid‐fast bacteria was negative and no inflammatory infiltrate was found. Based on these tests result, he was diagnosed with sarcoid‐like reaction secondary to pembrolizumab [duration of treatment to reaction onset and outcome not stated]. At the same time, a cytological evaluation of broncho‐alveolar lavage (BAL) showed lymphocytosis, normal total cell count, normal neutrophils and macrophages with no eosinophils, mast cells or plasma cells, which were consistent with the biopsy result and virtually excluded pneumonia and pneumonitis, respectively. Grosse A, et al. Diagnostic yield of broncho-alveolar lavage for pembrolizumab induced sarcoid-like reaction of the lung. Cytopathology 30: 686-687, No. 6, Nov 2019. 803500776 Available from: URL: http://doi.org/10.1111/cyt.12740
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Reactions 12 Sep 2020 No. 1821
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