Pentacam corneal densitometry-guided treatment of adenoviral corneal subepithelial infiltrates: a comparative study betw
- PDF / 738,494 Bytes
- 11 Pages / 547.087 x 737.008 pts Page_size
- 14 Downloads / 172 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL PAPER
Pentacam corneal densitometry-guided treatment of adenoviral corneal subepithelial infiltrates: a comparative study between transepithelial phototherapeutic keratectomy and topical tacrolimus Tarek Roshdy Elhamaky
Received: 12 May 2020 / Accepted: 16 August 2020 Springer Nature B.V. 2020
Abstract Purpose To compare the changes in the measurement of corneal densitometry and total corneal higherorder aberrations (HOAs) between topical tacrolimus and transepithelial phototherapeutic keratectomy (TePTK) in the treatment of adenoviral corneal subepithelial infiltrates (SEIs). Subject and methods This is an interventional prospective randomized study, including 63 eyes of 35 patients with symptomatic adenoviral corneal SEIs for at least 6 months. All patients underwent previous topical steroid therapy associated with unsatisfactory response and/or complications. Patients were assigned into three groups: (1) Te-PTK group: Te-PTK with MMC 0.02% was performed by a Technolas; Teneo excimer laser; (2) tacrolimus group: tacrolimus 0.03% ointment was applied once daily for 2–6 months; the endpoint of treatment was based on the improvement in the corneal densitometry, BCVA, and OSDI; and (3) control group: no intervention was done. BCVA, corneal densitometry, and total corneal higher-order
T. R. Elhamaky (&) Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Qalubiya Governorate 13511, Egypt e-mail: [email protected]; [email protected] T. R. Elhamaky Department of Ophthalmology, Ibn Nafees Medical Center, Abu Dhabi, UAE
aberrations (HOAs) evaluation using Pentacam HR were done at the baseline, 1 week, and then 1, 3, 6, and 12 months of the study. Results The study population was similar between all groups. The mean follow-up was 12.75 ± 0.9 months. Bilateral corneal SEI was recorded at 80%. At 12-month follow-ups, the mean BCVA improved in both the Te-PTK and tacrolimus groups without significant changes in the control group. The mean corneal densitometry of the anterior, central, and total cornea decreased significantly in the Te-PTK and tacrolimus groups. HO-RMS and total RMS decreased significantly in the Te-PTK and tacrolimus groups. BCVA, corneal densitometry (anterior, central, and total cornea), and corneal aberrations (total coma, total trefoil, HO-RMS, and total RMS) values were significantly better for the Te-PTK and tacrolimus groups than the control group. There were no statistically significant differences between Te-PTK and tacrolimus groups in terms of BCVA, corneal densitometry, corneal HOA, and the persistence of corneal SEIs. The persistence of corneal SEIs was significantly lower in Te-PTK and tacrolimus groups than the control group. Conclusion Te-PTK and topical tacrolimus are effective methods for the treatment of adenoviral corneal SEIs improving visual acuity, corneal densitometry, and corneal HOA. The densitometry program of the Pentacam may give an objective guide for the
123
Int Ophthalmol
tre
Data Loading...
