Pharmacogenomic Testing in Current Clinical Practice Implementation
While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for i
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Series Editors William B. Coleman Gregory J. Tsongalis
For other titles published in this series, go to www.springer.com/series/8176
Alan H.B. Wu • Kiang-Teck J. Yeo Editors
Pharmacogenomic Testing in Current Clinical Practice Implementation in the Clinical Laboratory
Editors Alan H.B. Wu University of California, San Francisco San Francisco General Hospital San Francisco, CA USA [email protected]
Kiang-Teck J. Yeo University of Chicago Department of Pathology Clinical Pharmacogenomics Program Chicago, IL USA [email protected]
ISBN 978-1-60761-282-7 e-ISBN 978-1-60761-283-4 DOI 10.1007/978-1-60761-283-4 Springer New York Dordrecht Heidelberg London © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
The “personalization” of therapeutics promises to deliver a more efficacious and cost-effective approach towards treating patients with chronic diseases. For many medications, the pharmaceutical industry’s objective of “one drug fits all individuals” has proven to be incorrect. Pharmacogenomics is an emerging discipline that will be essential for implementing personalized medicine. While there have been dozens of contemporary review articles on the science and specific application of pharmacogenomics to particular drugs, this book, “Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory” is the first compilation of the tests currently in routine clinical use. In this rapidly changing field, we recognize that a text of this type will be quickly outdated. Nevertheless, we have assembled chapters from the key authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. This book is designed as a reference to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics l
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