Pharmacokinetic Advantage of ASD Device Promote Drug Absorption through the Epicardium
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RESEARCH PAPER
Pharmacokinetic Advantage of ASD Device Promote Drug Absorption through the Epicardium Reyaj Mikrani 1,2 & Cunyu Li 1 & Muhammad Naveed 1,3 & Cuican Li 1 & Mirza Muhammad Faran Ashraf Baig 4 & Qin Zhang 1 & Yue Wang 5 & Juanjuan Peng 1 & Lingzhi Zhao 1 & Xiaohui Zhou 1,6,7
Received: 31 March 2020 / Accepted: 28 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
ABSTRACT Purpose Due to low therapeutic efficacy and severe adverse reaction of systemic administration for coronary heart disease (CHD) therapy, we designed a novel local target delivery system, called Active hydraulic ventricular Support Drug delivery system (ASD). This study aims to investigate the potential advantages of ASD compared to intrapericardial (IPC) injection and factors affecting drug absorption through epicardium. Methods Liposoluble, water soluble and viscous solutions of cyanine 5 (Cy5) fluorescent dye were delivered individually through ASD and IPC in Sprague-Dawley (SD) rats and then tissues were isolated and observed by in vivo imaging system.
Reyaj Mikrani and Cunyu Li are co-first authors
Atria and ventricles of the heart were taken for the paraffin section and observed under a fluorescence microscope. Results The fluorescence intensity of Cy5 injected by ASD distributed in the heart was significantly higher than IPC injection. Whereas, the fluorescence signal spread in other tissues such as lung, liver, spleen, and kidney of ASD groups was much weaker. Moreover, when choosing liposoluble and viscous Cy5, the intensity of the heart turned stronger and fluorescence dye distributed in other tissues was lesser. Conclusions The application of ASD device may provide a promising route of drug delivery for CHD. Furthermore, increasing viscosity of the solution and liposolublity of the drug was beneficial to facilitate drug absorption through the epicardium.
KEY WORDS Local targeted drug delivery system . liposolubility . viscosity . cardiac support device . ASD device
* Xiaohui Zhou [email protected]
INTRODUCTION 1
Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu 211198 Nanjing, People’s Republic of China
2
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, 3052 Victoria, Australia
3
School of Pharmacy , Nanjing Medical University , Jiangsu Nanjing, People’s Republic of China
4
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210023 Nanjing, People’s Republic of China
5
School of Sciences, Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Jiangsu Province 211198 Nanjing, China
6
Department of Surgery, Zhongda Hospital affiliated to Southeast University, Jiangsu Province 210017 Nanjing, People’s Republic of China
7
Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu 210017 Nanjing, Pe
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