Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs
Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algor
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Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs
Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs
Tony K.L. Kiang • Kyle John Wilby Mary H.H. Ensom Editors
Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs
Editors Tony K.L. Kiang
Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver BC Canada
Mary H.H. Ensom Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver BC Canada
Kyle John Wilby
College of Pharmacy Qatar University Doha Qatar
ISBN 978-981-10-2112-1 ISBN 978-981-10-2113-8 (eBook) DOI 10.1007/978-981-10-2113-8 Library of Congress Control Number: 2016959472 © Springer Science+Business Media Singapore 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Adis imprint is published by Springer Nature The registered company is Springer Science+Business Media Singapore Pte Ltd. The registered company address is: 152 Beach Road, #22-06/08 Gateway East Singapore 189721, Singapore
Acknowledgment
We thank Samuel E. Gilchrist, Ph.D. [email protected] for creating Fig. 1.1 specifically for this book.
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Contents
1 Introduction���������������������������������������������������������������������������������������������� 1 Kyle John Wilby, Tony K.L. Kiang, and Mary H.H. Ensom 2 HIV-Associated Comorbidities �������������������������������������������������������������� 9 Kyle John Wilby, Tony K.L. Kiang, and Mary H.H. Ensom 3 Pharmacology and Pharmacokinetic Properties of Available Antiretrovirals������������������������������������������������������������������������������������������ 15 Kyle John Wilby, Tony K.L. Kiang, and Mary H.H. Ensom 4 In Vitro Reaction Phenotyping and Drug Interaction Data���������������� 27 Tony K.L. Kiang, Kyle John Wilby, and Mary H.H. Ensom 5 Clinical Drug-Drug Interaction Data: Effects of Co-administered Drug
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