Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been applauded by students and&nbs
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Peter L. Bonate
Pharmacokinetic-Pharmacodynamic Modeling and Simulation Second Edition
Peter L. Bonate, Ph.D. Astellas Pharma Global Development Pharmacokinetics, Modeling, and Simulation Deerfield, IL USA
ISBN 978-1-4419-9484-4 e-ISBN 978-1-4419-9485-1 DOI 10.1007/978-1-4419-9485-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011930671 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to my family for their patience, support, and love.
Table of Contents Preface to the First Edition .................................................................................................................. xvii Preface to the Second Edition ............................................................................................................... xix Chapter 1: The Art of Modeling.............................................................................................................. 1 Introduction.............................................................................................................................................................................1 Pharmacometrics and Model-Based Drug Development .......................................................................................................1 What Is a Model and Why Are They Made? ..........................................................................................................................3 Modeling as Problem Solving.................................................................................................................................................5 Type of Models .......................................................................................................................................................................6 Properties of a Useful Model .........................................
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