Pharmacokinetics of Drugs
The author of this Foreword has recently retired after spending 25 years in academia and 15 years in the pharmaceutical industry. Most of this time has been spent following and, hopefully in some instances, contributing to advancement of the discipline of
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G.V.R.Born, London P. Cuatrecasas, Ann Arbor, MI D. Ganten, Berlin H. Herken, Berlin K.L. Melman, Stanford, CA
Pharmacokinetics of Drugs Contributors G.L. Amidon, J.P.F. Bai, L.P. Balant, C.M. Barksdale, I.A. Blair D.D. Breimer, M. Chiba, J. Delforge, M. Eichelbaum B.L. Ferraiolo, A.J. Fischman, M. Gex-Fabry, N. Holford J. Kantrowitz, H.K. Kroemer, T.M. Ludden, J.M. Mayer B. Maziere, C. McMartin, G. Mikus, M.A. Mohler G.D. Nordblom, R. O'Neill, K.S. Pang, O. Pelkonen A. Racine-Poon, R.H. Rubin, J.-L. Steimer, B.H. Stewart H.W. Strauss, B. Testa, S. Vozeh, P.G. Welling, R.J. Wills A. Yacobi
Editors
Peter G. Welling and Luc P. Balant With a Foreword by J.G. Wagner
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
PETER G. WELLING, Ph.D., D.Sc. Vice President Pharrnacokinetics/Drug Metabolism Parke-Davis Pharmaceutical Research Division Warner-Lambert Company 2800 Plymouth Road Ann Arbor, MI48105-1047 USA Luc P. BALANT, Ph.D. Reader Clinical Research Unit Department of Psychiatry 47, Rue du XXXI Decembre CH-1207 Geneva Switzerland
With 69 Figures and 51 Tables ISBN-13: 978-3-642-78682-2 e- ISBN-13: 978-3-642-78680-8 DOl: 10.1007/978-3-642-78680-8 Library of Congress Cataloging-in-Publication Data. Pharmacokinetics of drugs I contributors, Amidon, G.L. ... let al.]; editors, Peter G. Welling and Luc P. Balant. p. em. - (Handbook of experimental pharmacology; v. 110) Includes bibliographical references and index. ISBN-13:978-3-642-78682-2 1. Pharmacokinetics. I. Welling, Peter G. II. Balant, Luc P., 1941- . III. Series. QP905.H3 vol. 110 [RM301.5] 615'.1 s-dc20 [615' .7] 93-43145 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1994
Softcover reprint of the hardcover 1st edition 1994
The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Best-set Typesetter Ltd., Hong Kong SPIN: 10040028
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List of Contributors
AMIDON, G.L., University of Michigan, College of Pharmacy, Ann Arbor, MI 48109-106
