Physical functional limitations and psychological distress in people with and without colorectal cancer: findings from a
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Physical functional limitations and psychological distress in people with and without colorectal cancer: findings from a large Australian study Yuehan Zhang 1 & Grace Joshy 1
&
Kathryn Glass 1 & Emily Banks 1,2
Received: 17 March 2020 / Accepted: 30 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To quantify physical disability and psychological distress in people with and without colorectal cancer (CRC). Methods Questionnaire data (2006–2009) from 267,153 Australian general population members aged ≥ 45 years participating in the 45 and Up Study (n = 213,231 following exclusions) were linked to cancer registry and hospital admission data, to ascertain CRC status. Modified Poisson regression estimated adjusted prevalence ratios (PRs) for physical disability and psychological distress in participants with CRC versus those without. Results Compared with participants without CRC (n = 210,836), CRC survivors (n = 2395) had significantly higher physical disability prevalence (11.9% versus 19.5%, respectively), PR = 1.11 (95% CI = 1.03-1.20); and a similar prevalence of distress (23.1% versus 20.2%), PR = 1.03 (0.94-1.20). Adverse outcomes were associated with certain clinical characteristics. Compared with participants without CRC, CRC survivors diagnosed 5–< 10 and ≥ 10 years, with regional spread, and without recent cancer treatment had broadly similar outcomes; survivors with metastatic CRC and recent treatment had 30–60% higher prevalence of disability and distress. Compared with participants with neither CRC nor disability, PRs for distress were 4.71 (4.22–5.26) for those with disability and CRC; and 4.22 (4.13–4.31) for those with disability without CRC. Conclusions Physical disability is elevated in CRC survivors. Psychological distress is elevated 4- to 5-fold with disability, regardless of CRC diagnosis, with lesser increases around diagnosis and treatment. Implications for cancer survivors CRC survivors with less advanced disease and who have not been recently diagnosed or treated have physical disability and psychological distress comparable to the general population. Survivors with disability are at particularly high risk of psychological distress. Keywords Colorectal cancer . Physical functional limitations . Psychological distress . Clinical characteristics . Joint consideration
Introduction Colorectal cancer (CRC) is one of the most common cancers worldwide [1] and the third most common cancer in Australia Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11764-020-00901-y) contains supplementary material, which is available to authorized users. * Grace Joshy [email protected] 1
National Centre for Epidemiology and Population Health, Research School of Population Health, Australian National University, Canberra, ACT, Australia
2
The Sax Institute, Sydney, Australia
[2]. The 5-year survival for CRC in Australia has increased from 50 to 69% over the past three decades, with a 2013 estimate of almost 200,
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