PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma
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PRIMARY RESEARCH
Open Access
PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma Fen Liu1,4, Yan He1, Yong Liang1,5, Lijun Wen1, Yongming Zhu3, Yan Wu1, Lixiang Zhao1, Yunsen Li1, Xinliang Mao2 and Haiyan Liu1,2*
Abstract Background: Lup-20(29)-en-3H-ol (Lupeol), a dietary triterpene, has been shown to possess multiple pharmacological activities including anti-tumor effects Methods: In the current study, we noted that low doses of lupeol (
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