Plasma N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Intrinsic Capacity Decline in an Older Population
- PDF / 584,149 Bytes
- 7 Pages / 612 x 792 pts (letter) Page_size
- 10 Downloads / 201 Views
PLASMA N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE IS ASSOCIATED WITH INTRINSIC CAPACITY DECLINE IN AN OLDER POPULATION L. MA1, Y. ZHANG1, P. LIU1, S. LI1, Y. LI1, T. JI1, L. ZHANG1, J.K. CHHETRI2, Y. LI1 1. Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, Beijing, China; 2. Department of Neurology and Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing, China. Corresponding author: Lina Ma, M.D., Ph.D., Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, E-mail address: [email protected].
Abstract: Objectives: To determine the association between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and intrinsic capacity in an older population. Method: We recruited 283 participants aged 60–97 years (mean 77.42±4.08 years). Intrinsic capacity was assessed with the World Health Organization Integrated Care for Older People (ICOPE) screening tool including six domains: cognition, locomotion, vitality, hearing, vision, and psychology. Multimorbidity, polypharmacy, gait speed, physical activity, lifestyles, and chronic inflammation were assessed. We used multivariate logistic regression and the Spearman’s correlation to assess the association between plasma NT-proBNP and intrinsic capacity. Results: The average intrinsic capacity score was 4.53±1.34. The percentage of decreased intrinsic capacity was 75.3%. Participants with decreased intrinsic capacity were older, with more cardiovascular and cerebrovascular diseases and polypharmacy, and had lower gait speed and higher C-reactive protein. Plasma NT-proBNP was significantly higher in the decreased intrinsic capacity group (128.0[56.8-280.8] pg/mL vs. 72.6[39.7-120.0] pg/mL, p
Data Loading...
