Polyhydroxyalkanoate and its efficient production: an eco-friendly approach towards development
- PDF / 1,362,096 Bytes
- 14 Pages / 595.276 x 790.866 pts Page_size
- 73 Downloads / 155 Views
REVIEW ARTICLE
Polyhydroxyalkanoate and its efficient production: an eco‑friendly approach towards development Rutika Sehgal1 · Reena Gupta1 Received: 13 August 2020 / Accepted: 9 November 2020 © King Abdulaziz City for Science and Technology 2020
Abstract Polyhydroxyalkanoate (PHA) is the most promising solution to major ecological problem of plastic accumulation. The biodegradable and biocompatible properties of PHA make it highly demanding in the biomedical and agricultural field. The limited market share of PHA industries despite having tremendous demand as concerned with environment has led to knock the doors of scientific research for finding ways for the economic production of PHA. Therefore, new methods of its production have been applied such as using a wide variety of feedstock like organic wastes and modifying PHA synthesizing enzyme at molecular level. Modifying metabolic pathways for PHA production using new emerging techniques like CRISPR/Cas9 technology has simplified the process spending less amount of time. Using green solvents under pressurized conditions, ionic liquids, supercritical solvents, hypotonic cell disintegration for release of PHA granules, switchable anionic surfactants and even digestion of non-PHA biomass by animals are some novel strategies for PHA recovery which play an important role in sustainable production of PHA. Hence, this review provides a view of recent applications, significance of PHA and new methods used for its production which are missing in the available literature. Keywords Applications · Biodegradable plastic · Biosynthesis of PHA · Economic production · Molecular approach
Introduction The consistent accumulation of conventional synthetic plastic in environment has compelled us to think that there is an urgent need to replace it with biodegradable plastics. Polyhydroxyalkanoate (PHA) is the most promising solution to this major ecological problem. The properties of PHA make it close to plastics hence PHA bioplastic makes a good alternate which is biodegradable and biocompatible. Chemically, PHAs are in vivo polymerized polyoxoesters of hydroxyalkanoates (Sowinski et al. 2010) which are produced by microorganisms when there is carbon rich and nutrient (nitrogen, phosphorous, magnesium or sulfur) limiting condition for their energy and carbon storage (Koller * Reena Gupta [email protected] https://www.researchgate.net/profile/Reena_Gupta22 Rutika Sehgal [email protected] https://www.researchgate.net/profile/Rutika_Sehgal 1
Department of Biotechnology, Himachal Pradesh University, Summerhill, Shimla, Himachal Pradesh 171011, India
2018a, b). PHAs are produced in the form of water insoluble granules within the cytoplasm of the cell. PHA help microorganisms to survive under environmental stress conditions, and it is the key mechanism for their survival (Saharan et al. 2014). During starvation, the presence of PHA protects the cellular components such as RNA and proteins (Vinet and Zhedanov 2010) and it also plays an important role in sporulation.
Data Loading...
