Polymeric micelles for pulmonary drug delivery: a comprehensive review
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Polymeric micelles for pulmonary drug delivery: a comprehensive review Duy Toan Pham1,2 , Athittaya Chokamonsirikun2, Vipasiri Phattaravorakarn2, and Waree Tiyaboonchai2,3,* 1
Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho 900000, Vietnam Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, 99 Moo 9, Amphoe Muang, Phitsanulok 65000, Thailand 3 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Mahidol University, Salaya 73170, Thailand 2
Received: 21 July 2020
ABSTRACT
Accepted: 18 September 2020
Respiratory diseases have remained one of the most common diseases worldwide, in which oral and intravenous administration are the most common treatment routes. However, these administrative routes face various difficulties in reaching local pulmonary targets, possessing low efficacy, and have high risk of systemic side effects. To solve these issues, polymeric micelles represent an effective approach. These nano-ranged delivery systems can encapsulate and protect poorly water-soluble drugs, enhance drug targeting to the lung, reduce side effects, and improve drug efficacy via inhalation route. In this review, the importance of rational design was highlighted by summarizing the recent progress on the development of polymeric micelles in pulmonary delivery. Emphasis is also placed on the different types and preparations, as well as ideal properties and advantages of polymeric micelles for pulmonary route.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Annela M. Seddon. Duy Toan Pham, Athittaya Chokamonsirikun, and Vipasiri Phattaravorakarn have equally contributed to the paper
Address correspondence to E-mail: [email protected]
https://doi.org/10.1007/s10853-020-05361-4
J Mater Sci
GRAPHIC ABSTRACT
Introduction Respiratory diseases, both in acute and chronic forms, remain one of the most common diseases worldwide. More seriously, these diseases occur in all societies, age groups, and sectors, with an extremely high mortality rate of 20% of the world population. The most prevalent forms of respiratory disease are non-communicable ones, such as chronic obstructive pulmonary disease (COPD), asthma, chronic bronchitis, occupational lung diseases, and pulmonary hypertension [1]. To treat these diseases, various administrative routes have been utilized, including pulmonary (i.e., inhalation), oral, and intravenous injection. Oral and intravenous injection possess various disadvantages in terms of low drug bioavailability at the lung tissues (due to, i.e., firstpass metabolism) and unwanted systemic side effects [2–4]. Moreover, the intravenous route has relatively short duration of beneficial time and causes pain in local injection area, which might reduce patient compliance [5]. Therefore, pulmonary delivery has been the most widely used route due to its possibility to overcome all mentio
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