Polyvinylpyrrolidone- graft -poly(2-hydroxyethylmethacrylate) hydrogel membranes for encapsulated forms of drugs
- PDF / 2,355,361 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 76 Downloads / 132 Views
ORIGINAL PAPER
Polyvinylpyrrolidone‑graft‑poly(2‑hydroxyethylmethacrylate) hydrogel membranes for encapsulated forms of drugs Yuriy Melnyk1 · Yurij Stetsyshyn1 · Volodymyr Skorokhoda1 · Yuriy Nastishin2 Received: 24 April 2020 / Accepted: 28 October 2020 © The Polymer Society, Taipei 2020
Abstract Synthesis of the polyvinylpyrrolidone-graft-poly(2-hydroxyethylmethacrylate) hydrogel membranes while varying ratio between components, monomer concentration, chemical nature of the initiators and solvents, as well as temperature was investigated in details. Based on this study, optimal conditions of the polymerization formation of hydrogel membranes were established. The structural parameters of the hydrogel networks and their permeability for water and low molecular weight soluble substances were investigated. The main factors of effects on the structure of film hydrogels and their operational properties are established. The technological scheme of the formation of hydrogel membrane coatings for the fabrication of encapsulated forms of prolonged release of drugs is developed. Graphical abstract
Extended author information available on the last page of the article
13
Vol.:(0123456789)
354
Page 2 of 11
Journal of Polymer Research
(2020) 27:354
Keywords Polyvinylpyrrolidone · poly(2-hydroxyethylmethacrylate) · Hydrogel membranes · Grafted polymerization
Introduction Hydrogel materials are three-dimensional networks of polymer chains that are sometimes found as a colloidal gel in which water is the dispersion medium.1–2 Hydrogels are widely used for fabrication of contact lenses, therapeutic dressings, tissue scaffolds, osteoplastic materials for replacement of damaged bone tissue, implants, vehicles for drugs, in plastic surgery, and dentistry, including soft coatings in the areas of contact with mucous membranes.3–14 Depending on the nature of the cross-link junctions, hydrogels are classified either as chemical or physical hydrogels.15 In our opinion, the chemical modification of a polymer via graft copolymerization represents the most important possibility for improving the properties of the polymer and for the fabrication of hydrogel membranes. In,16–18 grafting copolymers of hydrophilic monomers, such as acrylamide, acrylic acid, and acrylonitrile, were synthesized by generating free radicals on the starch surface. In other works, to fabricate hydrogels the hydrophilic monomers were grafted onto a synthetic polymer, such as polyvinylpyrrolidone or poly(ethylene glycol). 19–23. Special attention should be paid to hydrogels based on grafting copolymers of 2-hydroxyethylmethacrylate (HEMA) with polyvinylpyrrolidone (PVP).19–22 This type of hydrogels is well-suitable as coatings for solid oral pharmaceutical compositions.24–26 Currently, the pharmaceutical industry uses the technology of coating of solid oral drug dosage forms mainly by water-soluble polymers.27 The film coating by such polymers allows one to control the release of the drug substance and its absorption in a desired place of the gastroint
Data Loading...
