Population data for 20 insertion-null allele markers in the Li ethnic minority from Hainan Province
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POPULATION DATA
Population data for 20 insertion-null allele markers in the Li ethnic minority from Hainan Province Jie Xu 1 & Lijuan Sun 2 & Xianwen Wang 1 & Xiehong Wang 1 & Weisheng Xing 1 & Pingmei Zhou 1 & Shujin Li 3 Received: 1 August 2020 / Accepted: 10 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Insertion/null polymorphisms (INNULs) can be used as an alternative marker of STRs to detect the highly degraded samples in forensic cases. In this study, we evaluated the genetic data of 20 INNUL markers in the Innotyper® 21 Human DNA Analysis Kit (InnoGenomics) for Hainan Li population, including allele frequencies and forensic parameters. No significant deviation from Hardy-Weinberg equilibrium and linkage disequilibrium was found in all loci after Bonferroni correction. The combined power of discrimination (CPD) was 0.99999891, the combined power of exclusion for duo paternity testing (CPEduo) was 0.75274389, and the combined power of exclusion for trio paternity testing (CPEtrio) was 0.94766143. These data would be useful for the application of the kit in practice and the research of the kit used in molecular anthropology studies. Keywords Genetic data . Insertion/null polymorphisms (INNULs) . Hainan Li population . Innotyper® 21 Human DNA Analysis kit
The Li ethnic group is one of the ethnic minorities in China, mainly living in the China’s second largest island—Hainan Island in the South China Sea. The Li group is the earliest inhabitants of the Hainan Island with the population of about 151 million by the year of 2018 [1]. They did not have their own written script; their spoken language belongs to the Chinese-Tibetan language family. According to the historical records, it is believed that the Li is inherited from the ancient Yue group, especially closed to the branch Luoyues. In this study, we investigated the genetic polymorphisms of the 20 insertion/null polymorphisms (INNULs) in Li ethnic minority from Hainan Island to provide population data for cases. Jie Xu and Lijuan Sun contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00414-020-02424-8) contains supplementary material, which is available to authorized users. * Shujin Li [email protected] 1
Criminal Technology Detachment of Haikou Public Security Bureau, Haikou, China
2
School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou, China
3
College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Shijiazhuang, China
INNULs are a similar type of markers to insertion/deletion polymorphisms (InDels) with bi-allelic nature. They are derived from the presence and absence of retrotransposable elements (REs) such as long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs) and distributed widely throughout the genome [2–4]. Some of them have small ampli
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