Population genetic study of a Peruvian population using human identification STRs
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Population genetic study of a Peruvian population using human identification STRs Carlos David Neyra Rivera 1 & Edgardo Delgado Ramos 2 & Cristian Saul Robles Mamani 2 & Margarita Rosa Eugenia Velasquez Reinoso 2 & Omar Alberto Caceres Rey 3 & Bruce Budowle 4 Received: 26 June 2020 / Accepted: 27 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract In this study, allele frequencies were determined in a Peruvian population for application to human identification. A population of 601 unrelated individuals was analyzed (400 individuals with the GlobalFiler Express kit and 201 individuals with the VeriFiler Express kit). The locus with the highest power of discrimination (PD) was SE33 (0.9851, 31 alleles), while the least polymorphic locus was D22S1045 (0.75810, 11 alleles). The PE in a similar fashion ranged from 0.2421 (D22S1045) to 0.7818 (SE33). Under the assumption of independence, the combined PD was > 0.9999999999 while the combined PE = 0.9999999933. When comparing the population studied with different populations of Latin America, the greatest Fst genetic distance was obtained with a Venezuelan population (0.052), and the shortest distance was with a Bolivian and Peruvian population (0.004). Keywords Allele frequencies . Human identification . Peruvian population . STR markers
For genetic identification purposes, studies of allele frequencies representative of the population are required. The most previous studies of allele frequencies conducted in Peru have used small populations (typically less than 100 individuals) and have used a subset of the markers (a few to 15 markers) being employed in most forensic laboratories and in available STR kits [1–5]. Such studies do not cover the current battery of markers and have substantial variance due to the small sample sizes.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00414-020-02418-6) contains supplementary material, which is available to authorized users. * Carlos David Neyra Rivera [email protected] 1
Universidad Científica del Sur, Carr. Panamericana Sur 19, Villa EL Salvador, 15067 Lima, Peru
2
Universidad Nacional Mayor de San Marcos, Ciudad Universitaria Cercado de Lima, 15081 Lima, Peru
3
Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud, Av. Defensores del Morro 2268 Chorrillos, 15064 Lima, Peru
4
Center for Human Identification, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
In this study, the population samples consisted of 601 unrelated adult individuals from different parts of Peru (Amazonas, Ancash, Apurímac, Arequipa, Ayacucho, Cajamarca, Callao, Cusco, Huancavelica, Huánuco, Ica, Junín, La Libertad, Lambayeque, Lima, Loreto, Madre de Dios, Moquegua, Pasco, Piura, Puno, San Martin, Tacna, Tumbes, and Ucayali). Before taking the sample, the participants signed the informed consent freely and voluntarily. Blood (4–6 drops) from a finger puncture was placed on a Nucleid Card (Copan).
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