Posterior segment inflammatory outcomes assessed using fluorescein angiography in the STOP-UVEITIS study
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ORIGINAL ARTICLE
International Journal of Retina and Vitreous Open Access
Posterior segment inflammatory outcomes assessed using fluorescein angiography in the STOP‑UVEITIS study Mohammad Ali Sadiq1, Muhammad Hassan2, Rubbia Afridi2, Muhammad Sohail Halim2, Diana V. Do2, Yasir J. Sepah2, and Quan Dong Nguyen2* for the STOP-UVEITIS Investigators
Abstract Background: Although fluorescein angiography (FA) is a frequently used imaging modality in patients with noninfectious uveitis (NIU), it has not been reliably used for objective assessment of posterior segment inflammatory outcomes in these patients. In this index study we report the posterior segment inflammatory outcomes of two different doses of intravenous (IV) infusions of tocilizumab (TCZ), an IL-6 inhibitor, in eyes with NIU using a semi-quantitative FA scoring system. Methods: STOP-Uveitis is a randomized, multi-center clinical trial conducted at 5 clinical centers across the United States. The study evaluated the role of TCZ in patients with NIU. Thirty-seven (37) patients with NIU were randomized into one of two treatment groups in a ratio of 1:1. Group 1 received IV infusions of 4 mg/kg TCZ and group 2 received IV infusions of 8 mg/kg TCZ. Infusions were given every 4 weeks in both groups until month 6 (primary endpoint). Posterior segment inflammatory outcomes were assessed by evaluating FA at baseline and month 6 by graders at a central reading center. A previously reported, semi-quantitative, scoring system for FA was used to assess signs that represent ongoing inflammatory processes in the posterior segment. These signs included optic disc hyperfluorescence, macular edema, retinal vascular staining and/or leakage, capillary leakage, retinal capillary nonperfusion, neovascularization of the optic disc, neovascularization elsewhere, pinpoint leaks, and retinal staining and/or subretinal pooling. Statistical significance was set at p
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