Potential Clinical Significance of the p53 Tumor Suppressor Gene in Cancer Patients
Mutations of p53 are common in a wide spectrum of tumors.1 They occur commonly in both non-small cell lung cancer (NSCLC) and small cell lung cancer cell lung cancer (SCLC), as well as breast, colon, head and neck, esophageal, hepatocellular and brain can
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P53 SuPPRESSOR GENE
MoLECUlAR BIOLOGY INTELLIGENCE UNIT
P53 SUPPRESSOR GENE Tapas Mukhopadhyay, Ph.D. Steven A. Maxwell, Ph.D. Jack A. Roth, M.D. University ofTexas M. D. Anderson Cancer Center Houston, Texas, U.S.A.
Springer-Verlag Berlin Heidelberg GmbH
RG. LANDEs CoMPANY AUSTIN
MoLEcULAR BIOLOGY lNTELLIGENCE UNIT P53 SUPPRESSOR GENE R.G. LANDES COMPANY Austin, Texas, U.S.A. Submitted: December 1994 Published: March 1995 U.S. and Canada Copyright © 1995 R.G. Landes Company All rights reserved.
International Copyright © 1995 Springer-Verlag Berlin Heidelberg Originally published by Springer-Verlag Berlin Heidelberg in 1995 Softcover reprint of the hardcover 1st edition 1995 All rights reserved. International ISBN 978-3-662-22277-5 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the rime of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library ofCongress Cataloging-in-Publication Data Mukhopadhyay, Tapas. p53 suppressor gene 1 Tapas Mukhopadhyay, Steven A. Maxwell, Jack A. Roth p. cm.--(Molecular biology intelligence unit) Includes bibliographical references and index. ISBN 978-3-662-22277-5 ISBN 978-3-662-22275-1 (eBook) DOI 10.1007/978-3-662-22275-1
1. p53 antioncogene. 1. Maxwell, Steven A. II. Roth, Jack A. III. Title. IV. Series. RC268. 44.P16M85 1995 616.99'4042--dc20 95-4045 CIP
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CONTENTS ===================:::::::::;-]
1. The Role ofp53 in Cancer .......................................... ................ 1 From Oncogene to Tumor Suppressor Gene ......................................... 1 Interactions with DNA Tumor Virus-Transforming Proteins ...
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