Practical Biostatistics in Translational Healthcare
There is an ever-increasing emphasis on evidence-based medicine that is distinguished by systematic crafting of the patient-centered research question, detailed literature searches, and careful appraisal of the resulting evidence. The consensus that ultim
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Allen M. Khakshooy Francesco Chiappelli
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Practical Biostatistics in Translational Healthcare
Allen M. Khakshooy · Francesco Chiappelli
Practical Biostatistics in Translational Healthcare
Allen M. Khakshooy Rappaport Faculty of Medicine Technion-Israel Institute of Technology Haifa, Israel
Francesco Chiappelli UCLA School of Dentistry Los Angeles, CA USA
ISBN 978-3-662-57435-5 ISBN 978-3-662-57437-9 (eBook) https://doi.org/10.1007/978-3-662-57437-9 Library of Congress Control Number: 2018943260 © Springer-Verlag GmbH Germany, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer-Verlag GmbH, DE part of Springer Nature. The registered company address is: Heidelberger Platz 3, 14197 Berlin, Germany
To master and apprentice, “Credette Cimabue ne la pittura tener lo campo, e ora ha Giotto il grido, … ” (Dante Alighieri, Divine Comedy, Purgatory XI 94,95)
Foreword
It is a great pleasure for me to write the Foreword of this interesting book on biostatistics and translational healthcare. Biostatistics is a rapidly evolving discipline. Large databases that collect massive information at individual level, coupled with high computing power, have increased enormously the potentiality of this discipline to a point that we can realistically speak of evidence-based patient-centered healthcare. However, the foundations of this discipline have not changed over time and lay on arguments that are inherently philosophical and logical. They also require a deep subject matter knowledge. All these issues are well addressed in the book, which constitutes a very good introduction to the principles of biostatistics. The book describes in detail the research process underlying the construction of what can be considered the scientific knowledge.
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