Modern Issues and Methods in Biostatistics
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a c
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Mark Chang
Modern Issues and Methods in Biostatistics
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Mark Chang AMAG Pharmaceuticals, Inc. Biometrics Hayden Ave. 100 02421 Lexington Massachusetts USA Statistics for Biology and Health Series Editors A. Tsiatis M. Gail Department of Statistics National Cancer Institute North Carolina State University Bethesda, MD 20892 Raleigh, NC 27695 USA USA Klaus Krickeberg W. Wong Le Chˆatelet Department of Statistics F-63270 Manglieu Stanford University France Stanford, CA 94305-4065 USA Jonathan M. Samet Department of Preventive Medicine Keck School of Medicine University of Southern California 1441 Eastlake Ave. Room 4436, MC 9175 Los Angles, CA 90089
ISSN 1431-8776 ISBN 978-1-4419-9841-5 e-ISBN 978-1-4419-9842-2 DOI 10.1007/978-1-4419-9842-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011931898 c Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. Biostatistics often requires innovations across disciplines. Over the years, biostatistics has gradually shaped its own unique characteristics and approaches. Indeed, the application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data w
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