Prediction of response to cardiac resynchronization therapy by cine- and velocity encoded cardiac magnetic resonance ima
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Poster presentation
Prediction of response to cardiac resynchronization therapy by cine- and velocity encoded cardiac magnetic resonance imaging Kai Muellerleile*, Loant Baholli, Michael Groth, Katharina Koopmann, Achim Barmeyer, Ralf Koester, Gerhard Adam, Gunnar K Lund and Stephan Willems Address: University Medical Center Hamburg-Eppendorf, Hamburg, Germany * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P63
doi:10.1186/1532-429X-12-S1-P63
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P63 © 2010 Muellerleile et al; licensee BioMed Central Ltd.
Introduction Quantification of mechanical dyssynchrony can help to identify responders to cardiac resynchronization therapy (CRT).
Purpose The purpose of the present study was to evaluate the ability of cine- and velocity encoded (VENC) magnetic resonance imaging (MRI) to predict response to CRT.
Methods
an area under the curve of 0.79 (P = 0.05) to predict response to CRT by measurements of SLMD. The area under the curve was 0.83 (P = 0.02) to predict response to CRT by VENC-MRI measurements of IVMD. Figure 1 demonstrates measurements of IVMD by VENC-MRI in a responder (IVMD = 92 ms, figure 1A) and a nonresponder (IVMD = 25 ms, figure 1 B) to CRT.
Conclusion Cine- and VENC-MRI have the ability to identify responders to CRT.
The study included twenty patients with heart failure NYHA class III and reduced ejection fraction (24 (18-28) %), scheduled for CRT device implantation. All patients underwent cine- and VENC-MRI before device implantation. Intra-ventricular dyssynchrony was measured by cine-MRI as the septal-to-lateral mechanical delay (SLMD). The inter-ventricular mechanical delay (IVMD) was assessed by VENC-MRI as the difference between onset of aortic and pulmonary flow. Clinical response to CRT was assessed at 6-month follow-up after device implantation.
Results Fourteen (70%) patients were classified as clinical responders to CRT. The SLMD and IVMD were longer in responders (336 (165-389) ms and 78 (25-105) ms) than in non-responders (49 (-25-335) ms and 9 (0-31) ms) to CRT (P = 0.05 and 0.02, respectively). Cine-MRI yielded Page 1 of 2 (page number not for citation purposes)
Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P63
http://jcmr-online.com/content/12/S1/P63
Figure 1
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