The role of cardiac magnetic resonance in diagnosis of cardiac sarcoidosis
- PDF / 3,286,339 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 175 Views
The role of cardiac magnetic resonance in diagnosis of cardiac sarcoidosis Marijana Tadic 1
&
Cesare Cuspidi 2,3 & Sahrai Saeed 4 & Bogomir Milojevic 5 & Isidora Grozdic Milojevic 6
Accepted: 30 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Sarcoidosis is a systemic granulomatous disease with a high prevalence of cardiac involvement in autopsic studies. Cardiac sarcoidosis is associated with increased cardiovascular morbidity and mortality. Endomyocardial biopsy is a specific technique, but unfortunately not sensitive enough. Non-invasive cardiac imaging has an important role in the evaluation of patients with suspected or confirmed cardiac sarcoidosis. Echocardiography remains the first choice imaging technique because of its availability and low cost. However, this method could not provide tissue characterization or evaluation of disease activity level. 18Ffluorodeoxyglucose (FDG) positron emission tomography (PET) has essential role in diagnosis and monitoring of patients with suspected or confirmed cardiac sarcoidosis. Nevertheless, more recently it has been shown that cardiac magnetic resonance (CMR) might provide useful information about cardiac sarcoidosis. Hybrid imaging approach that includes PET-CMR and PETCT is particularly interesting for diagnosis, assessment of activity and follow-up in these patients. Diagnostic algorithm in sarcoidosis patients should include clinical data, hybrid imaging and biopsy. Use of different CMR sequences such as cine imaging, late gadolinium enhancement, T1 and T2 mapping, as well as strain imaging, may significantly contribute to diagnosis and monitoring of patients with cardiac sarcoidosis. However, validation of these techniques and particularly T1 and T2 mapping in sarcoidosis patients in large studies is necessary. This review aimed to summarize current knowledge about clinical usefulness of CMR in patients with cardiac sarcoidosis. Keywords Cardiac sarcoidosis . Cardiac magnetic resonance . Positron emission tomography
Introduction Sarcoidosis is a systemic inflammatory granulomatous disease of unknown origin that is characterized by granulomas that consist of macrophages, surrounded by lymphocytes, which are usually located in the lungs and associated lymph nodes
* Marijana Tadic [email protected] 1
Department of Cardiology, University Hospital “Dr. Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, Belgrade 11000, Serbia
2
University of Milan-Bicocca, Milan, Italy
3
Istituto Auxologico Italiano, Clinical Research Unit, Viale della Resistenza 23, 20036 Meda, Italy
4
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
5
Clinic of Urology, Clinical Center of Serbia, Belgrade, Serbia
6
Center for Nuclear Medicine Clinical Center of Serbia, Belgrade, Serbia
[1]. The annual incidence of sarcoidosis is significantly higher among in African Americans than in Caucasians (35.5 vs. 10.9 per 100,000) [2]. Cardiac involvement in patients with systemic sarcoidosis was found in 25% o
Data Loading...
