Predictive, Preventive and Personalized Medicine: Leads From Ayurvedic Concept of Prakriti (Human Constitution)
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PRECISION MEDICINE AND PHARMACOGENOMICS (S NAIR, SECTION EDITOR)
Predictive, Preventive and Personalized Medicine: Leads From Ayurvedic Concept of Prakriti (Human Constitution) Rohit Sharma 1
&
Pradeep Kumar Prajapati 2
Accepted: 29 September 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose of Review Genomics has ushered in a phase of predictive, preventive and personalized medicine (PM), and several attempts are being made to detect genetic variations that are responsible for susceptibility to diseases and varied response to medications, however, have met with only a limited success. Ancient Indian system of medicine, Ayurveda, strongly emphasize on personalized patient care under the concept of Prakriti (phenotype-based human constitution). We would therefore like to put forward a new dimension of PM—the ‘Prakriti-based medicine’ bearing testable molecular and genetic correlates. Recent Findings Current investigations in the field of genomics, PM and Ayurveda have inspired many researchers and started in-depth deliberation on how Prakriti (phenotype-based Ayurveda constitution) is associated with the field of genomics, biochemistry, psychology, physiology and therapeutics. Various genotypes have also been correlated with Prakriti. Studies have shown wide range of utilities of Prakriti assessment in therapeutics, i.e. from predicting disease susceptibility of an individual, prevention of impending diseases, early diagnosis through screening of the high risk, rational drug designing, customization of therapy (drug, diet and lifestyle) and health maintenance. Summary Ayurvedic Prakriti-based treatment resonates with PM and pharmacogenomics and holds potential and promise for future predictive or preventive medicine. Further studies are warranted towards integrating or complementing genomics and contemporary medical science with Prakriti and explore the future possibilities. Keywords Ayurveda . Traditional Indian medicine . Pharmacogenomics . Personalized medicine . Prakriti . Tridosha
Introduction Decrypting human genome has steered current biomedical science towards a hope of revivifying contemporary symptomatic treatment approaches into personalized and predictive therapies depending upon an individual’s genetic makeup. Investigations in the past decade aptly introduced and mandated in-depth deliberation on how ‘personalized medicine This article is part of the Topical Collection on Precision Medicine and Pharmacogenomics * Rohit Sharma [email protected]; [email protected] * Pradeep Kumar Prajapati [email protected] 1
Department of Rasashastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India
2
Department of Rasashastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi 110076, India
(PM)’ is providing an impetus in shaping the future of medicine. PM or individualized medicine is a rapidly advancing therapeutic approach owing to its potential to transform and strengthe
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