Predictive value of vascular endothelial growth factor overexpression in early relapse of colorectal cancer patients aft
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ORIGINAL ARTICLE
Predictive value of vascular endothelial growth factor overexpression in early relapse of colorectal cancer patients after curative resection Hsiang-Lin Tsai & I-Ping Yang & Chih-Hung Lin & Chee-Yin Chai & Yu-Ho Huang & Chin-Fan Chen & Ming-Feng Hou & Chao-Hung Kuo & Suh-Hang Juo & Jaw-Yuan Wang Accepted: 14 August 2012 / Published online: 9 September 2012 # Springer-Verlag 2012
Abstract Background Preclinical and clinical studies have indicated that vascular endothelial growth factor (VEGF) is the predominant angiogenic factor. Recently, there was a consistent trend of poorer survival rates in colorectal cancer (CRC) patients of
earlier relapse. The purpose of this study was to investigate novel predictors of early relapse in stage I–III CRC and further to determine their correlation with disease outcomes. Materials and methods We retrospectively analyzed clinicopathological features and VEGF expression by
H.-L. Tsai Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
C.-F. Chen Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
H.-L. Tsai : M.-F. Hou : J.-Y. Wang (*) Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan e-mail: [email protected]
M.-F. Hou : J.-Y. Wang Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
H.-L. Tsai Program of Bachelor of Health Beauty, School of Medical and Health Sciences, Fooyin University, Kaohsiung, Taiwan I.-P. Yang Department of Nursing, Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan
M.-F. Hou : S.-H. Juo : J.-Y. Wang Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan C.-H. Kuo Department of Internal medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
C.-H. Lin : C.-Y. Chai Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
S.-H. Juo Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
C.-Y. Chai Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
S.-H. Juo Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
Y.-H. Huang Department of Anatomy, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
J.-Y. Wang Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
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immunohistochemical staining in 100 stage I–III CRC patients undergoing curative resection to identify predictors of postoperative early relapse. Results Among 100 patients, 40 patients were classified into early relapse group, and 60 patients were categorized into non-early relapse gr
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