Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of
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Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of a prospective randomized study Hiroyuki Inose1,15 · Tsuyoshi Kato1,2 · Hiroaki Nakamura3 · Masatoshi Hoshino3 · Daisuke Togawa4 · Toru Hirano5 · Yasuaki Tokuhashi6 · Tetsuro Ohba7 · Hirotaka Haro7 · Takashi Tsuji8 · Kimiaki Sato9 · Yutaka Sasao10 · Masahiko Takahata11 · Koji Otani12 · Suketaka Momoshima13 · Kunihiko Takahashi14 · Masato Yuasa1 · Takashi Hirai1 · Toshitaka Yoshii1 · Atsushi Okawa1 Accepted: 2 September 2020 © Springer Nature Switzerland AG 2020
Abstract Purpose No study has investigated the clinical and radiographic risk factors for the deterioration of quality of life (QOL) beyond 6 months after osteoporotic vertebral fractures (OVF). The purpose of this study was to identify the predictors associated with poor QOL improvement after OVF. Methods This post hoc analysis included 166 women aged 65–85 years with acute 1-level OVFs. For the patient-reported outcome measures, scores on the European Quality of Life-5 Dimensions (EQ-5D) scale, and visual analogue scale (VAS) for low back pain were used. Lateral radiography at 0, 12, and 48 weeks and magnetic resonance imaging (MRI) at enrollment and at 48 weeks were performed. The associations between baseline variables with change scores for EQ-5D were investigated using a multiple linear regression model. Results Univariate analysis showed that time since fracture, EQ-5D score, and VAS for low back pain at 0 week showed significant association with increased EQ-5D score from 0 to 48 weeks. According to the multiple regression analysis, the following equation was obtained: increased EQ-5D score from 0 to 48 weeks = 1.305 – 0.978 × EQ-5D at 0 week – 0.021 × VAS for low back pain at 0 week – 0.006 × age + (fluid-intensity T2-weighted MR image patterns: − 0.037, except for fluid-intensity T2-weighted MR image patterns: + 0.037). Conclusion In conclusion, older patients with severe low back pain and fluid-intensity T2-weighted MR image patterns were more likely to have lower QOL improvements after OVFs and may therefore need extra support to improve QOL Keywords Osteoporotic vertebral fracture · Risk factor · Quality of life · Visual analogue scale · European quality of life-5 dimensions
Introduction Vertebral fractures are the hallmark of osteoporosis and are commonly associated with deterioration in quality of life (QOL) [1]. While most acute vertebral fractures heal with kyphotic deformities and height loss, some vertebral fractures develop non-union [2]. Kyphotic deformities and/or non-union can often lead to reduced mobility and chronic pain, which limit everyday activities [3]. Reduced activities
* Hiroyuki Inose [email protected] Extended author information available on the last page of the article
can lead to increased isolation and can cause depression. Several reports have shown that patients with osteoporotic vertebral fractures (OVFs) suffer from a loss of independence [4, 5]. Collectively, these factors arising fro
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